The Theory of the Design of Experiments

Cox, D. R.; Reid, N.

doi:10.1201/9781420035834

Cited by 355 publications

(82 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We studied ≥5 mice for each of the (2×3×2×2 = 24) factorial combinations (“full factorial experiment”) [17]. This approach allowed us to study not only the individual effects (“main effects”) of each factor (mutation, diet, genetic background, and sex), but also whether the effect of a factor depended on other factors (“interactions”) (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Strain Background Modifies Phenotypes in the ATP8B1-Deficient Mouse

et al. 2010

View full text Add to dashboard Cite

BackgroundMutations in ATP8B1 (FIC1) underlie cases of cholestatic disease, ranging from chronic and progressive (progressive familial intrahepatic cholestasis) to intermittent (benign recurrent intrahepatic cholestasis). The ATP8B1-deficient mouse serves as an animal model of human ATP8B1 deficiency.Methodology/Principal FindingsWe investigated the effect of genetic background on phenotypes of ATP8B1-deficient and wild-type mice, using C57Bl/6 (B6), 129, and (B6-129) F1 strain backgrounds. B6 background resulted in greater abnormalities in ATP8B1-deficient mice than did 129 and/or F1 background. ATP8B1-deficient pups of B6 background gained less weight. In adult ATP8B1-deficient mice at baseline, those of B6 background had lower serum cholesterol levels, higher serum alkaline phosphatase levels, and larger livers. After challenge with cholate-supplemented diet, these mice exhibited higher serum alkaline phosphatase and bilirubin levels, greater weight loss and larger livers. ATP8B1-deficient phenotypes in mice of F1 and 129 backgrounds are usually similar, suggesting that susceptibility to manifestations of ATP8B1 deficiency may be recessive. We also detected differences in hepatobiliary phenotypes between wild-type mice of differing strains.Conclusions/SignificanceOur results indicate that the ATP8B1-deficient mouse in a B6 background may be a better model of human ATP8B1 deficiency and highlight the importance of informed background strain selection for mouse models of liver disease.

show abstract

Section: Resultsmentioning

confidence: 99%

Strain Background Modifies Phenotypes in the ATP8B1-Deficient Mouse

et al. 2010

View full text Add to dashboard Cite

show abstract

“…A statistical analysis of variance (ANOVA) is performed to identify the process parameters that are statistically significant. The optimal combination of the process parameters can then be predicted based on the above analysis [4][5][6][7][8].…”

Section: Description Of the Taguchi Methodsmentioning

confidence: 99%

Optimization of shot peening parameters using Taguchi technique

George

Pillai

Shah

2004

Journal of Materials Processing Technology

View full text Add to dashboard Cite

“…Randomization tests of no effect are often inverted to yield distribution free con dence intervals and Hodges-Lehmann point estimates for additive treatment effects. (See Lehmann 1998;Cox and Reid 2000;Rosenbaum 2002a, sec. 2, for recent textbook discussions of various aspects of randomization inference.…”

Section: Randomization Inference With Imperfect Compliancementioning

confidence: 98%