The TFOS International Workshop on Contact Lens Discomfort: Report of the Contact Lens Interactions With the Tear Film Subcommittee

Craig, Jennifer P.; Willcox, Mark; Argüeso, Pablo; Maïssa, Cécile; Stahl, Ulrike; Tomlinson, Alan; Wang, Jianhua; Yokoi, Norihiko; Stapleton, Fiona

doi:10.1167/iovs.13-13235

Cited by 177 publications

(161 citation statements)

References 399 publications

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“…Therefore, the surface-gel-layer water content does not vary over the reported range of tear-film physiological pH (i.e. 6.5-7.8) [39]. In all cases, the DAILIES TOTAL1 Ò surface-layer water content is significantly higher than that of the SiHy core, with core gravimetric water content identical to that of O 2 OPTIX™.…”

Section: Solute Partition Coefficientsmentioning

confidence: 73%

Fluorescent solute-partitioning characterization of layered soft contact lenses

Dursch

Liu

et al. 2015

Acta Biomaterialia

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a b s t r a c tPartitioning of aqueous packaging, wetting, and care-solution agents into and out of soft contact lenses (SCLs) is important for improving wear comfort and also for characterizing lens physico-chemical properties. We illustrate both features of partitioning by application of fluorescent-solute partitioning into DAILIES TOTAL1 Ò (delefilcon A) water-gradient SCLs, which exhibit a layered structure of a siliconehydrogel (SiHy) core sandwiched between thin surface-gel layers. Two-photon fluorescence confocal laser-scanning microscopy and attenuated total-reflectance Fourier-transform infrared spectroscopy (ATR-FTIR) characterize the lens and assess uptake profiles of six prototypical fluorescent solutes. Comparison of solute uptake in a SiHy-core prototype lens (i.e., O 2 OPTIX TM ) validates the core SiHy structure of DAILIES TOTAL1 Ò . To establish surface-layer charge, partition coefficients and water contents are obtained for aqueous pH values of 4 and 7.4. Solute fluorescence-intensity profiles clearly confirm a layered structure for the DAILIES TOTAL1 Ò lenses. In all cases, aqueous solute partition coefficients are greater in the surface layers than in the SiHy core, signifying higher water in the surface gels. ATR-FTIR confirms surface-layer mass water contents of 82 ± 3%. Water uptake and hydrophilic-solute uptake at pH 4 compared with that at pH 7.4 reveal that the surface-gel layers are anionic at physiologic pH 7.4, whereas both the SiHy core and O 2 OPTIX™ (lotrafilcon B) are nonionic. We successfully confirm the layered structure of DAILIES TOTAL1 Ò , consisting of an 80-lm-thick SiHy core surrounded by 10-lm-thick polyelectrolyte surface-gel layers of significantly greater water content and aqueous solute uptake compared with the core. Accordingly, fluorescent-solute partitioning in SCLs provides information on gel structure and composition, in addition to quantifying uptake and release amounts and rates.

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Section: Solute Partition Coefficientsmentioning

confidence: 73%

Fluorescent solute-partitioning characterization of layered soft contact lenses

Dursch

Liu

et al. 2015

Acta Biomaterialia

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“…Tear volume is a very important parameter regarding the comfort of the contact-lens wear. If TMV values drop, it could indicate discomfort in the contact-lens wear [51]. Some studies analyzed the possible variations on optical quality [52] and on visual performance [53] of daily disposable contact lenses during the day.…”

Section: Discussionmentioning

confidence: 99%

“…Material, water content and other lens parameters seems to play an important role in morphological changes of the cornea and in the quantity of the tear as well. The knowledge of changes in corneal thickness and, especially in TMV while wearing a particular type of daily disposable soft contact lens provides information about comfort and corneal health [51] and could provide valuable information for eye care practitioners, like which type of soft contact lens is better for a particular subject, especially when wearing time is considered. Differences in corneal thickness and in TMV variations could be attributed to inherent lens properties, such as material and water content.…”

Section: Discussionmentioning

confidence: 99%

Assessment of corneal thickness and tear meniscus during contact-lens wear

Águila-Carrasco

Ferrer-Blasco

García‐Lázaro

et al. 2015

Contact Lens and Anterior Eye

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“…Dry eye symptoms are commonly experienced by more than half of all contact lens wearers [1], with MGD being a possible cause of CLAD [1,56]. There has been an increasing awareness of the increased frequency of obstructive MGD in patients that are intolerant to contact lens wear [57,58].…”

Section: Non-contact Infrared Meibography In Contact Lens Wearersmentioning

confidence: 99%

Objective Metrics of Ocular Surface Disease in Contact Lens Wearers: Meibography

Qazi

Hamrah

2015

Curr Ophthalmol Rep

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Dry eye symptoms are very prevalent in contact lens wearers and are most commonly attributed to evaporative dry eye (EDE) due to alterations in the quality of the pre-lens tear film lipids. Meibomian gland dysfunction (MGD), the most common cause of EDE, may result in contact lens-associated dry eye and ultimately to intolerance to contact lens wear. Thus, a thorough assessment of meibomian glands and the eyelid margin prior to and during contact lens wear may ensure continuous contact lens tolerance and the maintenance of a healthy ocular surface. Since meibomian glands are not overtly visible on slit-lamp biomicroscopy, imaging methods such as infrared meibography could play an important role in the evaluation of meibomian gland health. This review discusses the most pertinent advances in infrared meibography and its application to contact lens wearers, with a focus on the utility of quantitative imaging methods in the evaluation of meibomian glands.

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The TFOS International Workshop on Contact Lens Discomfort: Report of the Contact Lens Interactions With the Tear Film Subcommittee

Cited by 177 publications

References 399 publications

Fluorescent solute-partitioning characterization of layered soft contact lenses

Fluorescent solute-partitioning characterization of layered soft contact lenses

Assessment of corneal thickness and tear meniscus during contact-lens wear

Objective Metrics of Ocular Surface Disease in Contact Lens Wearers: Meibography

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