The temperature course in acute myocardial infarction

Löfmark, Rurik; Nordlander, Rolf; Orinius, E.

doi:10.1016/0002-8703(78)90078-9

Cited by 22 publications

(14 citation statements)

References 6 publications

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“…Patients with MI, particularly large MIs, can manifest fever at presentation or during their hospital course, but it is particularly common in the first 24 hours after presentation and does not necessarily mean that an infection is present (18-21). However, it can often be a clinical challenge to determine whether the fever is due to the MI, to a complicating infection, or to other causes of systemic inflammation.…”

Section: Discussionmentioning

confidence: 99%

Serious Infection After Acute Myocardial Infarction

Truffa

Granger

White

et al. 2012

JACC: Cardiovascular Interventions

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Section: Discussionmentioning

confidence: 99%

Serious Infection After Acute Myocardial Infarction

Truffa

Granger

White

et al. 2012

JACC: Cardiovascular Interventions

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“…Based on the existence of this mechanism, currently, the blood leukocyte count is the subject of studies, not only in order to characterize it as an inflammatory marker, a fact that is proven, but also as a way to prove its relationship with cardiac events [13], increased mortality [14–16] and severity of myocardial infarction [17, 18]. In addition, it has been shown, too, that an increased white blood cell count signals a period of increased risk for recurrent ischemic events, where this increase precedes the risk by a week, and is associated with increased in-hospital mortality [19–21].…”

Section: Introductionmentioning

confidence: 99%

“…Although studies have already related the WBC count to the severity of myocardial infarction [17, 18] and increased mortality [14–16, 20], no one has correlated directly leukocyte count with the size of acute myocardial infarction with STEMI. Given this gap in the knowledge, this study presents the hypothesis that there is a correlation between leukocyte count and the STEMI size estimated by the area under the curve of myocardial necrosis markers.…”

Section: Introductionmentioning

confidence: 99%

Correlation between leukocyte count and infarct size in ST segment elevation myocardial infarction

Ferrari

Lueneberg

Silva

et al. 2016

Arch Med Sci Atheroscler Dis

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IntroductionRegarding the inflammatory mechanisms involved in ischemic heart disease, currently the leukocyte count is the subject of studies related to its association with the prognosis and mortality of ST segment elevation myocardial infarction (STEMI). Our aim is correlate the leukocyte count rise with the size of STEMI, evaluated with the area under the curve (AUC) and the peak of necrosis markers release.Material and methodsThis study is a sub-analysis of the TETHYS trial, a clinical trial that evaluated the effects of methotrexate in STEMI. We evaluated the correlation between quantitative variables with Pearson’s correlation, and the variables that did not follow a normal distribution were subjected to logarithmic transformation to base 10. The value of p < 0.05 indicated statistical significance.ResultsMales accounted for 73% of the participants, who had an average age of 59 years. A total of 58% were hypertensive and 53% smokers. The leukocyte count at hospital admission was significantly correlated with the AUC creatine kinase (CK) (r = 0.256, p = 0.021), troponin AUC (r = 0.247, p = 0.026), peak CK (r = 0.270, p = 0.015) and troponin peak (r = 0.233, p = 0.037). The leukocyte count at 72 h was significantly correlated with CK AUC (r = 0.238, p = 0.032), AUC of MB portion of CK (r = 0.240, p = 0.031) and peak CK (r = 0.224, p = 0.045).ConclusionsWhite blood cell count correlates with STEMI size assessed by serial cardiac biomarker levels.

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“…Body temperature may rise on average by more than 1°C as early as 4–8 h after onset of infarction and usually resolves by the 4th–5th day [2.] Sixty-six years ago, Master et al [3] stated that fever was one of the cardinal signs of coronary thrombosis and a reliable guide to the severity of infarction[.…”

Section: Introductionmentioning

confidence: 99%

Body Temperature – A Marker of Infarct Size in the Era of Early Reperfusion

Ben‐Dor¹,

Haim²,

Rechavia³

et al. 2005

Cardiology

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We measured body temperature in 40 consecutive patients treated for a first ST elevation acute myocardial infarction (AMI) with primary percutaneous coronary interventions. Left ventricular function was assessed by echocardiography, and blood samples were drawn for highly sensitive C-reactive protein (hs-CRP), white blood cell (WBC) count, fibrinogen, creatine kinase (CK), and cardiac troponin I levels (cTnI). The median (25th, 75th quartiles) peak 24-hour temperature was 37.4°C (36.9°C, 37.6°C). Variables significantly associated with peak 24-hour temperature were CK (p = 0.01, r = 0.42), wall motion index (p = 0.01, r = 0.41), hs-CRP (p = 0.01, r = 0.41), and cTnI (p = 0.03, r = 0.35). There was no significant correlation between peak 24-hour temperature and WBC count (p = 0.39, r = 0.14) and fibrinogen (p = 0.12, r = 0.21). Thus, peak 24-hour body temperature after ST elevation AMI probably reflects infarct size rather than a nonspecific inflammatory response.

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The temperature course in acute myocardial infarction

Cited by 22 publications

References 6 publications

Serious Infection After Acute Myocardial Infarction

Serious Infection After Acute Myocardial Infarction

Correlation between leukocyte count and infarct size in ST segment elevation myocardial infarction

Body Temperature – A Marker of Infarct Size in the Era of Early Reperfusion

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