volume 23, issue 4, P542-549 2008
DOI: 10.1016/j.jcrc.2007.09.004
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Abstract: The phenotypic and functional changes observed in neutrophils in the critically ill indicate that they require a higher level of stimulus to become activated. This may represent an auto-protective mechanism where the neutrophils in the already inflamed host may, by this mechanism, avoid excessive inflammation reducing the risk of further host cell injury and death.

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