The symptoms of patients with CKD stage 5 managed without dialysis

Brennan, Frank; Collett, Gemma; Josland, Elizabeth; Brown, Mark

doi:10.1179/1743291x14y.0000000118

Cited by 20 publications

(21 citation statements)

References 9 publications

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“…Total POS‐S renal score was strongly correlated with overall QOL and subdomains of QOL suggesting symptoms pervasively affect all QOL health domains. The most prevalent symptoms in both dialysis and ND groups were also most severe; consistent with previous research of patients with ESKD managed conservatively . There was an unexpected, small but significant difference in physical domains of health‐related QOL scores, with dialysis patients scoring lower than ND patients, suggesting treatment burden with dialysis.…”

Section: Discussionsupporting

confidence: 86%

Patient‐reported outcome measures and their utility in the management of patients with advanced chronic kidney disease

et al. 2019

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Symptoms in patients with advanced kidney disease are common and are associated with reduced quality of life, health satisfaction and functional status. In addition to this, this study shows symptoms are associated with increased risk of mortality over 12 months suggesting a novel approach to consider symptoms in prognostic assessments. ABSTRACT:Symptom and quality of life (QOL) measures in patients with advanced chronic kidney disease are recognized indicators of patient-centred care and represent important research, quality and clinical measures. This study examined relationships between symptom burden, QOL and functional status and associations of symptoms and mortality risk. A multisite longitudinal cohort analysis was undertaken in chronic kidney disease stage 4/5 (no dialysis) and dialysis patients. Patients completed symptom and QOL measures (Palliative Care Outcome Symptom Score renal), World Health Organisation QOL Brief Version) and Karnofsky Performance scale. Clinical and demographic data were recorded. SUPPORTING INFORMATIONAdditional supporting information may be found in the online version of this article at the publisher's website:Appendix S1 Patient-reported outcome measures.

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Section: Discussionsupporting

confidence: 86%

Patient‐reported outcome measures and their utility in the management of patients with advanced chronic kidney disease

et al. 2019

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“…Prevalence studies of patients with ESKD being managed with dialysis or conservatively show that patients experience a large constellation of symptoms. [2][3][4] One symptom that has received limited attention is alteration in taste. Food, drink, and their enjoyment are significant nutritional, cultural, and social phenomena.…”

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confidence: 99%

The Pathophysiology and Management of Taste Changes in Chronic Kidney Disease: A Review

Brennan

Stevenson

Brown

2020

Journal of Renal Nutrition

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“…Nausea (including dry-retching) and vomiting affect approximately 29% and 12% of the conservatively managed population, respectively. 35 In advanced CKD, elevated urea can produce a bitter tastant, which is sensed by taste buds found throughout the gastrointestinal tract, and can result in nausea, dry-retching and vomiting. 38 Because this may be chronically present and vary in intensity over time, strategies to neutralize salivary urea concentration and reduce circulating urea levels should be explored (Table 5).…”

Section: Nausea Dry-retching and Vomitingmentioning

confidence: 99%

“…Nausea (including dry‐retching) and vomiting affect approximately 29% and 12% of the conservatively managed population, respectively . In advanced CKD, elevated urea can produce a bitter tastant, which is sensed by taste buds found throughout the gastrointestinal tract, and can result in nausea, dry‐retching and vomiting .…”

Section: Nutrition‐impact Symptomsmentioning

confidence: 99%

Nutrition in Renal Supportive Care: Patient‐driven and flexible

et al. 2017

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Renal Supportive Care is an alternative treatment pathway in advanced chronic kidney disease that is being increasingly adopted, particularly in the elderly. Renal Supportive Care uses principles of palliative care and has been developed to enhance the care for dialysis patients with a high symptom burden and those being managed on a non‐dialysis pathway. Nutrition management is often an under‐recognized component of care and can play an important role in improving patients' quality of life to reduce symptom burden, support physical function and independence and provide appropriate counselling to patients and their families to ensure the goals of Renal Supportive Care are met. Nutrition interventions need to target patient and treatment goals, with frequent monitoring to ensure patient needs are being met. This review outlines available literature on this topic and suggests some practical ways in which nutrition can be enhanced for these patients.

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The symptoms of patients with CKD stage 5 managed without dialysis

Cited by 20 publications

References 9 publications

Patient‐reported outcome measures and their utility in the management of patients with advanced chronic kidney disease

Patient‐reported outcome measures and their utility in the management of patients with advanced chronic kidney disease

The Pathophysiology and Management of Taste Changes in Chronic Kidney Disease: A Review

Nutrition in Renal Supportive Care: Patient‐driven and flexible

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