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“…Second, even if CT regeneration would occur in operated mice, its time course would not be sufficiently fast to affect results of our behavioral tests. In several studies of CT regeneration in mice (Yasumatsu et al 2003, 2007; Shigemura et al 2005), surgery was designed to facilitate regeneration: the CT was exposed at ∼5 mm rostrally to its entry to the bulla and crushed so that nerve sheath would remain (to facilitate regrowth of neurons along the path of the peripheral part of the nerve). In these studies, the size of the taste buds in the fungiform papillae decreased after the nerve crush, and it returned to presurgical level at 3 weeks after surgery (Shigemura et al 2005).…”
Section: Discussionmentioning
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“…Second, even if CT regeneration would occur in operated mice, its time course would not be sufficiently fast to affect results of our behavioral tests. In several studies of CT regeneration in mice (Yasumatsu et al 2003, 2007; Shigemura et al 2005), surgery was designed to facilitate regeneration: the CT was exposed at ∼5 mm rostrally to its entry to the bulla and crushed so that nerve sheath would remain (to facilitate regrowth of neurons along the path of the peripheral part of the nerve). In these studies, the size of the taste buds in the fungiform papillae decreased after the nerve crush, and it returned to presurgical level at 3 weeks after surgery (Shigemura et al 2005).…”
Section: Discussionmentioning
“…In several studies of CT regeneration in mice (Yasumatsu et al 2003, 2007; Shigemura et al 2005), surgery was designed to facilitate regeneration: the CT was exposed at ∼5 mm rostrally to its entry to the bulla and crushed so that nerve sheath would remain (to facilitate regrowth of neurons along the path of the peripheral part of the nerve). In these studies, the size of the taste buds in the fungiform papillae decreased after the nerve crush, and it returned to presurgical level at 3 weeks after surgery (Shigemura et al 2005). Taste-evoked nerve activity was only partially restored 3 weeks after surgery, and it returned to a presurgical level only 5 or more weeks after surgery (Yasumatsu et al 2003, 2007).…”
Section: Discussionmentioning
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