The suppressive effect of dietary coenzyme Q₁₀ on mitochondrial reactive oxygen species production and oxidative stress in chickens exposed to heat stress

Abstract

This study was conducted to determine if dietary supplementation with coenzyme Q (CoQ ), which can act as a potent antioxidant and is an obligatory cofactor of mitochondrial uncoupling protein, suppresses the heat stress (HS)-induced overproduction of mitochondrial reactive oxygen species (ROS) and oxidative damage in the skeletal muscle of birds. The carbonyl protein content of skeletal muscle was significantly higher in birds exposed to HS treatment (34°C, 12 h) than in thermoneutral birds (25°C). This increase was suppressed by CoQ supplementation (40 mg/kg diet). Succinate-supported mitochondrial ROS production was increased by HS treatment, and this increase was also suppressed by CoQ supplementation. In contrast, CoQ supplementation did not affect the HS-induced decrease in mitochondrial proton leak. The mitochondrial membrane potential (ΔΨ), to which HS-induced ROS production was previously shown to be sensitive, tended to be increased by HS treatment, but this rise in ΔΨ was not affected by CoQ supplementation. Taken together, these results suggest that dietary CoQ supplementation attenuates HS-induced oxidative damage to skeletal muscle, by preventing the overproduction of succinate-supported mitochondrial ROS in a manner that is independent of ΔΨ. © 2015 Japanese Society of Animal Science.

Recent Advances in Biomarkers for Parkinson’s Disease

“…Reactive oxygen species (ROS) make great contribution to the pathophysiology of PD. Coenzyme Q10 (CoQ10) is an antioxidant that facilitates function of the mitochondrial electron transport chain (Kikusato et al, 2016 ). In vivo and in vitro trials showed that the defect in the activity of mitochondrial complex 1 in PD patients will lead to the disruption of redox equilibrium and neuronal toxicity.…”

Effect of Heat Stress on the Expression of HSP70, UCP3 and CYP450 Genes in Liver; Longissimus Dorsi and Semitendinosus Muscle of Growing Pigs

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