All the known isotopes of the elements Fm through Og are neutron-deficient relative to β-stability. In this contribution, I discuss two methods of producing more n-rich heavy nuclei, i.e., the use of radioactive nuclear beams (RNBs) and the use of multi-nucleon transfer (MNT) reactions. In the former case, I discuss recent studies of the interaction of 39,46 K with 181 Ta and their implications for the synthesis of more n-rich isotopes of Bh and Hs. In the case of MNT reactions, I discuss recent results for the reaction of 136 Xe with 208 Pb, 204 Hg + 198 Pt, and 136 Xe + 198 Pt. I compare measured distributions of the target-like fragments (TLFs) and projectile-like fragments (PLFs) with current models of MNT reactions.