The successful use of -omic technologies to achieve the ‘One Health’ concept in meat producing animals

Farschtschi, Sabine; Riedmaier-Sprenzel, Irmgard; Phomvisith, Ouanh; Gotoh, Takafumi; Pfaffl, Michael W.

doi:10.1016/j.meatsci.2022.108949

Cited by 4 publications

(3 citation statements)

References 155 publications

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“…The disclosure of illicit doping practices in farmed animals is still difficult in European countries due to the misuse of several classes of both "old and forgotten" or "new and unknown" drugs combined with more and more refined administration schedules on animals. Considering the recent choices of EU countries to set up risk-based monitoring plans, designed to potentially have the flexibility needed to effectively contrast these practices [42], the untargeted methods will represent an ideal tool to contrast animal doping, being based on omic approaches that could allow both retrospective analysis and the refinement of existing targeted strategies [43]. In this monitoring framework, the use of identified transcriptional biomarkers has confirmed how the transcriptomics approach can be a useful tool for the indirect detection of the misuse of anabolic steroids in fattening pigs.…”

Section: Discussionmentioning

confidence: 99%

RNAseq Analysis of Livers from Pigs Treated with Testosterone and Nandrolone Esters: Selection and Field Validation of Transcriptional Biomarkers

Benedetto,

Šťastný,

Giaccio

et al. 2023

Animals

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The use of anabolic–androgenic steroids (AASs) as growth promoters in farm animals is banned in the European Union, representing both an illicit practice and a risk for consumer health. However, these compounds are still illegally administered, often in the form of synthetic esters. This work aimed to characterize significant coding RNA perturbations related to the illicit administration of testosterone and nandrolone esters in fattening pigs. A total of 27 clinically healthy 90-day-old pigs were randomly assigned to test and control groups. Nine animals were treated with testosterone esters (Sustanon®) and other nine with nandrolone esters (Myodine®). At the end of the trial, liver samples were collected and analyzed using RNAseq, allowing the identification of 491 differentially expressed genes (DEGs). The transcriptional signature was further characterized by a smaller sub-cluster of 143 DEGs, from which a selection of 16 genes was made. The qPCR analysis confirmed that the identified cluster could still give good discrimination between untreated gilt and barrows compared to the relative testosterone-treated counterparts. A conclusive field survey on 67 liver samples collected from pigs of different breeds and weight categories confirmed, in agreement with testosterone residue profiles, the specificity of selected transcriptional biomarkers, showing their potential applications for screening purposes when AAS treatment is suspected, allowing to focus further investigations of competent authorities and confirmatory analysis where needed.

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Section: Discussionmentioning

confidence: 99%

RNAseq Analysis of Livers from Pigs Treated with Testosterone and Nandrolone Esters: Selection and Field Validation of Transcriptional Biomarkers

Benedetto,

Šťastný,

Giaccio

et al. 2023

Animals

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“…Currently, the One Health perspective for research that unifies animal, human, and environmental health, requires multidisciplinary approaches to deepen the understanding of microbial communities that inhabit a given environment (Oliveira et al, 2023;Banerjee & van der Heijden, 2023;Zinsstag et al, 2018;Farschtschi et al, 2022;Hilborn & Beasley, 2015). An increasing amount of evidence suggests that experimental strategies including global analyses of DNA, RNA, metabolites, and proteins (areas of research classified as "omics") promising alternatives to conducting One Health studies (Gruszecka-Kosowska et al, 2022;Tigistu-Sahle et al, 2023) and the possibility to assess these studios in a variety of environments, ecosystems or conditions.…”

Section: Analysis Of the Core Diversity Of The Microbiotamentioning

confidence: 99%

Identification of potentially harmful bacterial genera of veterinary relevance in the Llanquihue urban wetlands

Rocha,

Opitz,

Cárdenas

et al. 2024

Austral J Vet Sci

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Water bodies constitute natural, social, and ecological heritage under constant threat from the footprint of human action. They are the habitats of many species and play a key role in sustaining biodiversity in different ecosystems. However, anthropogenic activity can result in eutrophication of water bodies, favoring the excessive growth of microorganisms, which can be a risk factor for animal, human, and environmental health. The Agricultural and Livestock Service [Servicio Agrícola y Ganadero, (SAG)] of Chile developed a list of Mandatory Reportable Diseases (MRD) to report suspected contagious diseases of veterinary relevance. In this sense, the detection of microorganisms in water bodies for the characterization of their sanitary status is important for the development of monitoring strategies and the prevention of possible diseases. This study aimed to determine the presence of potentially harmful bacteria in Llanquihue urban wetlands. Here, we used metagenomic sequencing of amplicons to characterize the composition of microorganisms in three urban wetlands in the city of Llanquihue, which could be a risk factor for animal health. Our main finding was the detection of genera that may be associated with MRD, in addition to other microbial genera that have pathogenic potential. On the other hand, we also report the presence of cyanobacteria genera that can be involved in toxin production in water bodies as another potential source of risk. This is the first study to use massive sequencing techniques to analyze the sanitary status of urban wetlands in the city of Llanquihue.

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“…activity, according to Nazir & Kaleem (2021), contributes to technological growth and development within organizations. Farschtschi et al (2022) indicate that companies operate in a highly dynamic and competitive environment, making it essential to control their information to remain competitive; therefore, according to Altmann et al (2022), they seek alternatives in technologies applied to information management to evolve over time, reduce costs, and seek customer satisfaction. Additionally, according to Lukinskiy et al (2022), data management technology tools have evolved along with the more intensive use of the concept of dynamic and contingent data management in any organization.…”

Section: Review Articlementioning

confidence: 99%

Technologies applied to information control in organizations: A review

Panduro

2023

DecisionTech Rev

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In the contemporary global market, organizations face intense competition requiring the deployment of information technology (IT) for effective decision-making and to maintain market presence. This review article emphasizes the crucial role of information technologies in organizational decision-making processes. It outlines the evolution of data management tools, especially in the context of dynamic and contingent data management, and explores the adoption and implementation of technologies for information control within organizations. By analyzing various methodologies and results from existing research, the article illustrates the increasing reliance on IT to enhance organizational processes, decision-making, and overall competitiveness. Furthermore, it delves into the systematic review approach to understand the significance and application of information management technologies in organizational contexts, offering insights for entrepreneurs and academics. The review concludes with the assertion that proper information management through technology is vital for organizations to remain competitive in the ever-changing market landscape.

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The successful use of -omic technologies to achieve the ‘One Health’ concept in meat producing animals

Cited by 4 publications

References 155 publications

RNAseq Analysis of Livers from Pigs Treated with Testosterone and Nandrolone Esters: Selection and Field Validation of Transcriptional Biomarkers

RNAseq Analysis of Livers from Pigs Treated with Testosterone and Nandrolone Esters: Selection and Field Validation of Transcriptional Biomarkers

Identification of potentially harmful bacterial genera of veterinary relevance in the Llanquihue urban wetlands

Technologies applied to information control in organizations: A review

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