The SU.VI.MAX Study

Herçberg, Serge; Galán, Pilar; Preziosi, Paul; Bertrais, Sandrine; Mennen, Louise; Malvy, Denis; Roussel, Anne‐Marie; Favier, Alain; Briançon, Serge

doi:10.1001/archinte.164.21.2335

Cited by 848 publications

(201 citation statements)

References 42 publications

(5 reference statements)

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“…However, several studies could not find significant effectiveness of vitamin E on prevention of cancer, 4,7-25 reduction in cardiovascular diseases, 8,13,25-36 and overall mortality reduction. 5,15,19,25,27,[37][38][39] In a randomized, double-blind, placebo-controlled trial (The Physicians' Health Study II), a total of 14641 male physicians aging more than 50 years were enrolled. They received supplements of vitamin E (400 IU) every other day and were followed for 8 years.…”

Section: Vitamin E (α-Tocopherol)mentioning

confidence: 99%

Vitamins, Are They Safe?

Hamishehkar¹,

Ranjdoost²,

Asgharian³

et al. 2016

Adv Pharm Bull

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Section: Vitamin E (α-Tocopherol)mentioning

confidence: 99%

Vitamins, Are They Safe?

Hamishehkar¹,

Ranjdoost²,

Asgharian³

et al. 2016

Adv Pharm Bull

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“…It may be easier to convince people to take an inexpensive MVM supplement than to markedly change their eating habits. Evidence is accumulating that a MVM supplement, or smaller combinations of vitamins and minerals, also improve long-term health, reducing heart disease, cancer, and cataracts and improving immune function for those who consume inadequate diets (122)(123)(124)(125)(126)(127)(128)(129)(130)(131)(132)(133)(134)(135)(136)(137)155). The potential benefits of an MVM in infection have been critically reviewed (138).…”

Section: Should People Take An Mvm Supplement For Insurance?mentioning

confidence: 99%

“…For all of these reasons it is unlikely that it will be possible to obtain definitive results from this type of RCT, whether it be targeted at single micronutrients or MVMs. For example, two very large RCTs examined effects of supplementation with a limited number of vitamins and minerals on cancer risk (134,135). Although both of these RCTs reported a reduction in cancer incidence or mortality with supplementation, methodological concerns have been raised to argue that the results are not definitive (156).…”

Section: Should People Take An Mvm Supplement For Insurance?mentioning

confidence: 99%

Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage

Ames¹

2006

Proc. Natl. Acad. Sci. U.S.A.

337

231

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Inadequate dietary intakes of vitamins and minerals are widespread, most likely due to excessive consumption of energy-rich, micronutrient-poor, refined food. Inadequate intakes may result in chronic metabolic disruption, including mitochondrial decay. Deficiencies in many micronutrients cause DNA damage, such as chromosome breaks, in cultured human cells or in vivo. Some of these deficiencies also cause mitochondrial decay with oxidant leakage and cellular aging and are associated with late onset diseases such as cancer. I propose DNA damage and late onset disease are consequences of a triage allocation response to micronutrient scarcity. Episodic shortages of micronutrients were common during evolution. Natural selection favors short-term survival at the expense of long-term health. I hypothesize that short-term survival was achieved by allocating scarce micronutrients by triage, in part through an adjustment of the binding affinity of proteins for required micronutrients. If this hypothesis is correct, micronutrient deficiencies that trigger the triage response would accelerate cancer, aging, and neural decay but would leave critical metabolic functions, such as ATP production, intact. Evidence that micronutrient malnutrition increases late onset diseases, such as cancer, is discussed. A multivitamin-mineral supplement is one low-cost way to ensure intake of the Recommended Dietary Allowance of micronutrients throughout life.

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“…O estudo SU.VI.MAX (The Supplémentation en Vitamines et Minéraux Antioxydants) que acompanhou milhares de franceses durante 7,5 anos recebendo doses diárias de ácido ascórbico, α-tocoferol e β-caroteno concluiu que a redução da incidência de câncer e da mortalidade foi significativa entre as pessoas do sexo masculino. Estes apresentavam deficiência nos níveis plasmáticos dos antioxidantes administrados antes do estudo 84 . Esta intervenção seguiu os moldes do estudo de Linxian no que diz respeito às doses da suplementação, próximas às recomendações nutricionais preconizadas nos Estados Unidos.…”

Section: Perspectivas Estudos Promissoresunclassified

Antioxidantes dietéticos: controvérsias e perspectivas

Cerqueira¹,

Medeiros²,

Augusto³

2007

Quím. Nova

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Recebido em 10/10/05; aceito em 20/4/06; publicado na web em 10/1/07 DIETETIC ANTIOXIDANTS: CONTROVERSIES AND PERSPECTIVES The generation of reactive oxygen and nitrogen species (ROS and RNS) during metabolism is capable of damaging cellular biomolecules. To be protected against oxidative injury, cells evolved complex cellular defense mechanisms and the capability to use exogenous antioxidants to eliminate ROS/RNS. The potential role of micronutrients as antioxidants (vitamin C, vitamin E, carotenoids and poliphenols) has stimulated intense research efforts. In various human supplementation studies, however, these compounds presented pro-oxidant effects at high doses for most risk groups. Therefore, more studies about the bioavailability, tissue uptake, metabolism and biological activities should be performed before establishing recommendations for disease prevention.Keywords: antioxidant vitamins; carotenoids; poliphenols. INTRODUÇÃOOs organismos vivos interagem com o meio ambiente visando manter um ambiente interno que favoreça a sobrevivência, o crescimento e a reprodução. O oxigênio molecular (O 2 ) obtido da atmosfera é vital para organismos aeróbios; contudo, espécies reativas formadas intracelularmente a partir do oxigênio ameaçam a integridade celular por meio da oxidação de biomoléculas, e podem comprometer processos biológicos importantes 1 .O dano oxidativo de biomoléculas pode levar à inativação enzimática, mutação, ruptura de membrana, ao aumento na aterogenicidade de lipoproteínas plasmáticas de baixa densidade e à morte celular. Estes efeitos tóxicos do oxigênio têm sido associados ao envelhecimento e ao desenvolvimento de doenças crôni-cas, inflamatórias e degenerativas 2 .A despeito deste paradoxo, a vida aeróbia tornou-se possível graças às adaptações biológicas que levaram ao desenvolvimento de defesas antioxidantes contra a toxicidade do oxigênio e espécies derivadas deste. As adaptações biológicas às mudanças do meio ambiente guiam o processo evolutivo. Neste sentido, as adaptações podem ser definidas como características que se tornam aumentadas e mantidas sob seleção 1 .Embora as defesas antioxidantes endógenas sejam efetivas, não são infalíveis, e constantemente há formação de espécies reativas de oxigênio e de nitrogênio (ROS/RNS) que interagem em diferentes níveis com o ambiente celular antes de serem eliminadas, o que, à primeira vista, pode parecer uma falha evolutiva. Todavia, há evidências recentes de que um certo nível destas espécies é imprescindível para muitas funções fisiológicas. Por ex., o enovelamento de proteínas nascentes no retículo endoplasmático ocorre em um meio mais oxidante que o restante da célula para a formação de pontes dissulfeto 1 . Também, muitos genes são transcritos após oxidação transitória e baixas concentrações de alguns oxidantes estimulam a proliferação celular, como exemplificado pela adição de 1 μM de H 2 O 2 à cultura de células 3 .Os componentes celulares não são protegidos totalmente por antioxidantes endógenos, e é bem estabelecido que antioxidant...

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The SU.VI.MAX Study

Abstract: After 7.5 years, low-dose antioxidant supplementation lowered total cancer incidence and all-cause mortality in men but not in women. Supplementation may be effective in men only because of their lower baseline status of certain antioxidants, especially of beta carotene.

Cited by 848 publications

References 42 publications

Vitamins, Are They Safe?

Vitamins, Are They Safe?

Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage

Antioxidantes dietéticos: controvérsias e perspectivas

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