U. Derewenda, A. Mateja, Y. Devedjiev, K.M. Routzahn, A.G. Evdokimov, Z.S. Derewenda, D.S. Waugh
The complex array of functions attributed to LcrV has Although a crystal structure of this protein has been effectively stymied efforts to elucidate its mechanisms actively sought for better understanding of its role of action. Attempts to study structure-function relationin pathogenesis, the wild-type LcrV was found to be ships by deletion analysis and site-directed mutagenerecalcitrant to crystallization. We employed a surface sis have yielded little useful information because they entropy reduction mutagen…
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