The structure of pathozoospermia in young men with post-pubertal visceral obesity and a non-aggravated andrologic anamnesis

Роживанов, Р. В.; Викторович, Роживанов Роман; Kurbatov, D G; Геннадьевич, Курбатов Дмитрий

doi:10.14341/omet2017432-37

Cited by 5 publications

(1 citation statement)

References 14 publications

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“…Роживанов и Д.Г. Курбатов [49]. Несмотря на то что не всегда удавалось провести клинические параллели между повышением уровня АФК в сперме с показателями спермограммы и частотой наступления беременности [50], появились доказательства повышения вероятности успеха протоколов ВРТ после применения антиоксидантов [51], в том числе с участием мужчин, имевших избыточный вес.…”

Section: обзоры литературыunclassified

Male infertility, metabolic syndrome and obesity

Korneyev

Matsueva

2021

Urology reports (St. - Petersburg)

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The review article is devoted to the current understanding of the mechanisms that can have a negative impact on the reproductive function of men with metabolic syndrome and obesity. The article presents the results of clinical studies proving the existence of a relationship between the severity of metabolic disorders, copulatory activity, ejaculate parameters, the likelihood of pregnancy, as well as the health of the offspring.

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Section: обзоры литературыunclassified

Male infertility, metabolic syndrome and obesity

Korneyev

Matsueva

2021

Urology reports (St. - Petersburg)

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Semen quality indicators associated with reduced body weight in young infertile men with pathozoospermia, postpubertal visceral obesity and normal andrological history

2020

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Background: Considering the negative impact of visceral obesity on fertility, it is important to study semen quality indicators associated with reduced body weight.Aims: Evaluation of semen quality indicators associated with reduced body weight in patients with infertility, postpubertal visceral obesity and normal andrological history.Materials and methods: 33 infertile men under 30 years with post-pubertal and alimentary visceral obesity were included into retrospective case-control study. All patients have been followed through a six month weight loss program (hypocaloric diet, daily aerobic physical activity). The waist circumference, blood lipid levels, seminal antioxidant capacity and scanning electron microscopy analysis were determined before and after weight loss program. At the end of the study, patients were divided into two groups according to weight loss. The first group reduced their body weight by 5% or more (n=16), second group didn’t achieve the goal (n=17).Results: Statistically significant differences were identified in the ejaculate parameters between patients of two groups. Though at the time of initiation of medical intervention two groups were comparable except for body mass, after six months in the first group the number of sperm in 1 ml ejaculate, morphologically normal forms and the total antioxidant capacity of ejaculate increased while the number of sperm DNA integrity decreased.Conclusion: In young men with postpubertal visceral obesity and normal andrological history clinically significant body weight reduction is associated with improved semen quality indicators.

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Ejaculate quality indicators of men with asthenozoospermia and asthenoteratozoospermia by treatment of obesity with liraglutide

2021

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Background: Considering the influence of visceral obesity on male infertility, the investigation of ejaculate quality indicators under obesity treatment is relevant.Objective: Evaluation of ejaculate quality indicators by obesity treatment with liraglutide in andrologically healthy men with infertility and post-pubertal visceral obesity.Methods: Infertile men with post-pubertal alimentary visceral obesity were included in a pilot observational prospective study. All patients were given recommendations for body weight loss (hypocaloric diet, daily aerobic physical activity) as well as an average daily dose of liraglutide 2.4 [2.4; 3.0] mg. Evaluation of waist circumference, antioxidant activity of ejaculate, spermogram was carried out initially and after 6 months. The differences were considered statistically significant at p <0.005.Results: The body weight decrease was -11.7 [12.4; 11.0]%, the waist circumference decrease was 8 [12; 7] cm. In dynamics, increased content of living sperm in ejaculate from 92 [90; 95]% to 95 [92; 98]%, morphologically normal forms from 5 [3; 6]% to 6 [3; 8]%, mobility of A + B from 25 [15; 36] to 35 [19; 52]%, seminal antioxidant capacity, a decrease in reactive oxygen forms in the neat ejaculate were statistically significant. Increasing the sperm count in 1 ml and decreasing reactive oxygen forms in the washed ejaculate did not reach statistical significance.Conclusion: Ejaculate quality indicators improved by the complex obesity therapy with liraglutide in young andrologically healthy men with postpubertal visceral obesity.

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The structure of pathozoospermia in young men with post-pubertal visceral obesity and a non-aggravated andrologic anamnesis

Cited by 5 publications

References 14 publications

Male infertility, metabolic syndrome and obesity

Male infertility, metabolic syndrome and obesity

Semen quality indicators associated with reduced body weight in young infertile men with pathozoospermia, postpubertal visceral obesity and normal andrological history

Ejaculate quality indicators of men with asthenozoospermia and asthenoteratozoospermia by treatment of obesity with liraglutide

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