The structure and functions of lactoferrin and its role in human reproduction (a review)

Сухарев, А. Е.; Николаев, А. А.; Sucharev, A. E.

doi:10.17116/repro201521625-30

Cited by 3 publications

(1 citation statement)

References 66 publications

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“…Currently, the following functions of lactoferrin and ferritin are described. These are iron homeostasis, differentiation, and growth of cells of various types, antimicrobial protection, as well as anti-inflammatory and antitumor properties [3][4][5][6][7]. Immune properties of lactoferrin and ferritin are also actively studied in breast cancer.…”

Section: Topicalitymentioning

confidence: 99%

The Role of Iron-Containing proteins in the Correctio of the Immune Status of Menopausal Women Diagnosed with Breast Cancer

2022

IGWHC

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Section: Topicalitymentioning

confidence: 99%

The Role of Iron-Containing proteins in the Correctio of the Immune Status of Menopausal Women Diagnosed with Breast Cancer

2022

IGWHC

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Protective properties of lactoferrin in spermatogenesis disorders

Meredov,

Mavlyutova,

Ploskonos

et al. 2024

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Objective of the study: to evaluate the protective effect of lactoferrin on improving spermatogenic function in testicular dysfunction caused by low-intensity electromagnetic radiation of the millimeter range. Materials and methods: 48 mature male rats were used. They were divided into four groups: a control group, a group exposed to low-intensity electromagnetic radiation of the millimeter range, a group of lactoferrin with oral intake of lactoferrin 10 mg per day, a group of combined irradiation with lowintensity electromagnetic radiation of the millimeter range and taking lactoferrin. Testicular spermatogenesis was assessed using traditional methods. Testicular tissue homogenate was used for Western blot analysis. Serum testosterone concentrations were determined using enzyme-linked immunosorbent assay (ELISA) kits. Data were analyzed using one-way analysis of variance (ANOVA). A statistical difference was accepted at p < 0.05. Results. Low-intensity electromagnetic radiation in the millimeter range causes a significant decrease in sperm concentration by almost 2 times (51.7 % of the control). Combined oral administration of lactoferrin with low-intensity millimeter-wave electromagnetic radiation has a protective effect on sperm concentration. Electromagnetic radiation in the millimeter range causes a significant decrease in testosterone production in the testicles. Oral administration of lactoferrin during radiation maintained normal testosterone levels. Lactoferrin also improves the integrity of the blood-testis barrier, which is compromised by exposure to millimeter-wave radiation. Millimeter-wave radiation significantly reduces the expression of claudin 11 by 40 %. The combined use of millimeter-wave radiation and oral administration of lactoferrin maintains claudin 11 production at control levels. Irradiation significantly reduces the production of N-cadherin; the combined use of irradiation and oral administration of lactoferrin does not restore the level of this protein. Conclusion. Taken together, the results showed that lactoferrin ameliorated spermatogenesis and integral aspects of the blood-testis barrier that were compromised by exposure to millimeter-wave radiation, which was achieved by improving the integrity of the blood-testis barrier, restoring claudin-11 expression, as well as restoring testosterone levels.

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Comparative Analysis of Dental Status of Pregnant Women

Miklaev¹

2020

Medicine and Physical Education: Science and Practice

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Currently, oral diseases require an interdisciplinary approach to solving the problem. In most cases, patients go to a doctor during an acute stage or exacerbation of the disease. The high prevalence and increase of inflammatory oral diseases among pregnant women is one of the most significant social problems. Inflammatory processes in the oral cavity can be a provoking factor for the inflammatory reaction of the whole body and subsequently affect the development of the fetus. During pregnancy, a number of changes occur in the oral cavity in the woman's body: the microbiological picture changes, the pathogenicity of the microflora increases, the hormonal background is rebuilt: the production of progesterone, chorionic gonadotropin and other hormones increases. All these factors can lead to changes in the dentate system: deterioration of oral hygiene, increased salivation, halitosis, the appearance of gum bleeding and a change in the pH of saliva. We presented data on the examination of pregnant women in the Tambov Region. We assessed dental status of pregnant women based on dental indices: CPITN, PMA and H.R. Muhleman’s gum bleeding index, estimates of changes in saliva pH of pregnant women.

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The structure and functions of lactoferrin and its role in human reproduction (a review)

Cited by 3 publications

References 66 publications

The Role of Iron-Containing proteins in the Correctio of the Immune Status of Menopausal Women Diagnosed with Breast Cancer

The Role of Iron-Containing proteins in the Correctio of the Immune Status of Menopausal Women Diagnosed with Breast Cancer

Protective properties of lactoferrin in spermatogenesis disorders

Comparative Analysis of Dental Status of Pregnant Women

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