The Structural Basis of Ligand Perception and Signal Activation by Receptor Kinases

Hohmann, Ulrich; Lau, Kelvin; Hothorn, Michael

doi:10.1146/annurev-arplant-042916-040957

Cited by 231 publications

(275 citation statements)

References 153 publications

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“…Recent reports suggest that SERK1 could function as a cell surface common coreceptor that regulates the activity of receptors involved in different cell differentiation processes (Aan den Toorn et al , Hohmann et al , Santiago et al , Zhang et al ). Named after its discovery in somatic cells with embryogenic competence (Schmidt et al ), there is still very little known about the nature of the ligand it helps to bind to during embryogenesis or the signal transduction pathway activated after the heterodimeric complex binds its ligand.…”

Section: Discussionmentioning

confidence: 99%

Ectopic expression of the Coffea canephora SERK1 homolog‐induced differential transcription of genes involved in auxin metabolism and in the developmental control of embryogenesis

Pérez-Pascual

Jiménez-Guillen

Villanueva-Alonzo

et al. 2018

Physiologia Plantarum

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Somatic embryogenesis receptor-like kinase 1 (SERK1) is a membrane receptor that might serve as common co-regulator of plant cell differentiation processes by forming heterodimers with specific receptor-like kinases. The Coffea canephora SERK1 homolog (CcSERK1) was cloned in this work, and its early function in the transcription of embryogenesis master genes and of genes encoding proteins involved in auxin metabolism was investigated by externally manipulating its expression in embryogenic leaf explants, before the appearance of embryogenic structures. Overexpression of CcSERK1 early during embryogenesis caused an increase in the number of somatic embryos when the 55-day process was completed. Suppression of CcSERK1 expression by RNA interference almost abolished somatic embryogenesis. Real time-PCR experiments revealed that the transcription of the CcAGL15, CcWUS, CcBBM, CcPKL, CcYUC1, CcPIN1 and CcPIN4 homologs was modified in direct proportion to the expression of CcSERK1 and that only CcLEC1 was inversely affected by the expression levels of CcSERK1. The expression of the CcYUC4 homolog was induced to more than 80-fold under CcSERK1 overexpression conditions, but it was also induced when CcSERK1 expression was silenced. The level of CcTIR1 was not affected by CcSERK1 overexpression but was almost abolished during CcSERK1 silencing. These results suggest that CcSERK1 co-regulates the induction of somatic embryogenesis in Coffea canephora by early activation of YUC-dependent auxin biosynthesis, auxin transport mediated by PIN1 and PIN4, and probably auxin perception by the TIR1 receptor, leading to the induction of early-stage homeotic genes (CcAGL15, CcWUS, CcPKL and CcBBM) and repression of late-stage homeotic genes (CcLec1).

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Section: Discussionmentioning

confidence: 99%

Ectopic expression of the Coffea canephora SERK1 homolog‐induced differential transcription of genes involved in auxin metabolism and in the developmental control of embryogenesis

Pérez-Pascual

Jiménez-Guillen

Villanueva-Alonzo

et al. 2018

Physiologia Plantarum

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“…Interestingly, plants, insects, mice, and humans employ LRR RLKs to recognize epitopes derived from the same conserved microbial structures, such as bacterial flagellum, supporting the possibility of an evolutionarily ancient concept of a eukaryotic non‐self‐recognition system (Nürnberger et al ). In all these kingdoms, ligand binding triggers dimerization and/or conformational changes within the receptor proteins and subsequently activates downstream signaling events, leading to a signal‐specific cellular program (Bessman et al ; Hohmann et al ).…”

Section: Introductionmentioning

confidence: 99%

The crossroads of receptor‐mediated signaling and endocytosis in plants

Claus

Savatin

Russinova

2018

JIPB

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Plants deploy numerous plasma membrane receptors to sense and rapidly react to environmental changes. Correct localization and adequate protein levels of the cell-surface receptors are critical for signaling activation and modulation of plant development and defense against pathogens. After ligand binding, receptors are internalized for degradation and signaling attenuation. However, one emerging notion is that the ligand-induced endocytosis of receptor complexes is important for the signal duration, amplitude, and specificity. Recently, mutants of major endocytosis players, including clathrin and dynamin, have been shown to display defects in activation of a subset of signal transduction pathways, implying that signaling in plants might not be solely restricted to the plasma membrane. Here, we summarize the up-to-date knowledge of receptor complex endocytosis and its effect on the signaling outcome, in the context of plant development and immunity.

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“…Ligands primarily bind to their receptors in a noncovalent manner, often via hydrogen bonds or hydrophobic interactions (Hohmann et al, 2017). Ligand binding can induce the formation of multimeric complexes involving activated receptors, coreceptors, and intracellular kinases (Couto and Zipfel, 2016).…”

Section: Rlks Regulate Ros Production and Signaling (Ros Downstream Omentioning

confidence: 99%

“…In contrast to signaling molecules that interact with macromolecular domains within receptor proteins (Hohmann et al, 2017; Table 1), ROS directly modify amino acid residues, most prominently cysteine and methionine. This activity results in covalent oxidative posttranslational modifications (PTMs) of a large pool of potential ROS targets (Figure 2A).…”

Section: Ros Are Perceived Via Oxidative Posttranslational Modificationsmentioning

confidence: 99%

Bound by Fate: The Role of Reactive Oxygen Species in Receptor-Like Kinase Signaling

et al. 2017

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In plants, receptor-like kinases (RLKs) and extracellular reactive oxygen species (ROS) contribute to the communication between the environment and the interior of the cell. Apoplastic ROS production is a frequent result of RLK signaling in a multitude of cellular processes; thus, by their nature, these two signaling components are inherently linked. However, it is as yet unclear how ROS signaling downstream of receptor activation is executed. In this review, we provide a broad view of the intricate connections between RLKs and ROS signaling and describe the regulatory events that control and coordinate extracellular ROS production. We propose that concurrent initiation of ROS-dependent and -independent signaling linked to RLKs might be a critical element in establishing cellular responses. Furthermore, we discuss the possible ROS sensing mechanisms in the context of the biochemical environment in the apoplast. We suggest that RLK-dependent modulation of apoplastic and intracellular conditions facilitates ROS perception and signaling. Based on data from plant and animal models, we argue that specific RLKs could be components of the ROS sensing machinery or ROS sensors. The importance of the crosstalk between RLK and ROS signaling is discussed in the context of stomatal immunity. Finally, we highlight challenges in the understanding of these signaling processes and provide perspectives for future research.

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The Structural Basis of Ligand Perception and Signal Activation by Receptor Kinases

Cited by 231 publications

References 153 publications

Ectopic expression of the Coffea canephora SERK1 homolog‐induced differential transcription of genes involved in auxin metabolism and in the developmental control of embryogenesis

Ectopic expression of the Coffea canephora SERK1 homolog‐induced differential transcription of genes involved in auxin metabolism and in the developmental control of embryogenesis

The crossroads of receptor‐mediated signaling and endocytosis in plants

Bound by Fate: The Role of Reactive Oxygen Species in Receptor-Like Kinase Signaling

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