The strain-specific involvement of nucleus accumbens in latent inhibition might depend on differences in processing configural- and cue-based information between C57BL/6 and DBA mice

Differential involvement of the dorsal hippocampus in passive avoidance in C57bl/6J and DBA/2J mice

“…The opposite effects of pre-exposure provide further evidence for a differential utilization of the hippocampus in PA learning in these two strains of mice since the hippocampus plays a role in latent inhibition of contextual fear conditioning (reviewed by Maren and Holt, 2000). Latent inhibition effects in both strains have been reported in auditory fear conditioning after pre-exposure to the auditory cue (Gould and Wehner, 1999;Restivo et al, 2002). Latent inhibition to explicit cues such as a tone also depends on the entorhinal cortex serving as the major sensory input to the hippocampus (Lewis and Gould, 2007;Seillier et al, 2007).…”

Are DBA/2 mice associated with schizophrenia-like endophenotypes? A behavioural contrast with C57BL/6 mice

“…increased number of CS-US pairings or contextual change between pre-exposure and conditioning) would be highly relevant. One previous study has reported that 16 CS pre-exposures (distributed across 4 days) followed by two CS-US pairings in a conditioned freezing paradigm led to LI in DBA/2 but not C57BL/6 mice (Restivo et al 2002), but the statistical evidence provided was weak, and careful examination revealed that their test condition was far from ideal-with a trend of LI effect obtained in C57BL/6 mice, reportedly at p=0.06.…”

“…Baruch et al 1988;Gray et al 1992;Williams et al 1998), and it has been suggested that a distinction between pathological traits associated with positive and negative symptoms of schizophrenia can be achieved by appropriate parametric variation of the LI paradigm (see Weiner 2003). Such manipulation was included here, thus allowing an important extension to previous studies of LI expression in DBA/2 mice (Baarendse et al 2008;Gould and Wehner 1999;Restivo et al 2002). Finally, we also evaluated in the comparison between DBA/2 and C57BL/6 mice whether the former would exhibit pharmacologically induced phenotypes that are in keeping with the dopamine and glutamate/N-methyl-D-aspartic acid (NMDA) hypotheses of schizophrenia (c.f.…”

Reelin haploinsufficiency reduces the density of PV+ neurons in circumscribed regions of the striatum and selectively alters striatal-based behaviors

“…Latent inhibition was assessed in the contextual fear conditioning apparatus described above according to a previously described protocol (Restivo et al 2002). Mice (16 rl/+ and 16 +/+) were placed in the conditioning chamber for a 2-min free exploration period.…”