The Storage Conditions of High-Fat Diet Are the Key Factors for Diet-Induced Obesity and Liver Damage

Yi, Chuanyou; Li, Dandan; Guo, Xiao; Wang, Jinhui; Liu, Cenxi; Lu, Guangxing; Sun, Yan; Huang, He; Hong, Shangyu; Li, Jin

doi:10.3390/nu14112222

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…For instance, the fat content and ratio in HFD vary from study to study, although they are all called HFD. Third, even though the diets fed to animals are better controlled, the diet storage condition also makes difference (Yi et al 2022). Fourth, the environment in different animal facilities affects the microbiota in the animals.…”

Section: Discussionmentioning

confidence: 99%

Diets, Gut Microbiota and Metabolites

Liu

Zhong

et al. 2023

Phenomics

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The gut microbiota refers to the gross collection of microorganisms, estimated trillions of them, which reside within the gut and play crucial roles in the absorption and digestion of dietary nutrients. In the past decades, the new generation 'omics' (metagenomics, transcriptomics, proteomics, and metabolomics) technologies made it possible to precisely identify microbiota and metabolites and describe their variability between individuals, populations and even different time points within the same subjects. With massive efforts made, it is now generally accepted that the gut microbiota is a dynamically changing population, whose composition is influenced by the hosts' health conditions and lifestyles. Diet is one of the major contributors to shaping the gut microbiota. The components in the diets vary in different countries, religions, and populations. Some special diets have been adopted by people for hundreds of years aiming for better health, while the underlying mechanisms remain largely unknown. Recent studies based on volunteers or diet-treated animals demonstrated that diets can greatly and rapidly change the gut microbiota. The unique pattern of the nutrients from the diets and their metabolites produced by the gut microbiota has been linked with the occurrence of diseases, including obesity, diabetes, nonalcoholic fatty liver disease, cardiovascular disease, neural diseases, and more. This review will summarize the recent progress and current understanding of the effects of different dietary patterns on the composition of gut microbiota, bacterial metabolites, and their effects on the host's metabolism. KeywordsGut microbiota • Metabolites • Diets • Nutrients • Metabolic diseases Abbreviations NAFLD Nonalcoholic fatty liver disease CVD Cardiovascular disease LPS Lipopolysaccharide BCAA Branched-chain amino acid SCFA Short-chain fatty acid * Shangyu Hong

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Section: Discussionmentioning

confidence: 99%

Diets, Gut Microbiota and Metabolites

Liu

Zhong

et al. 2023

Phenomics

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Microwave heating instead of blanching to produce low-fat French fries

Zhang

Lyu

Aadil

et al. 2023

Innovative Food Science & Emerging Technologies

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Daily replacement of very high-fat diet stabilizes food intake and improves mouse welfare by ensuring food quality

Cordeira

2023

PLoS ONE

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Researchers are obligated to ensure food quality and provide laboratory animals with a palatable diet. Factors influencing the quality and palatability of very high-fat diet (VHFD), a widely used rodent diet, however, are understudied. We conducted experiments to establish best practices for ensuring the quality of VHFD and to improve mouse welfare. We found that VHFD in the food hopper was vulnerable first to dehydration and then oxidation within 7-days, leading to dramatic changes in food intake and food preference behavior in mice. Mitigating dehydration and oxidation of VHFD by replacing food daily, rather than weekly, stabilized feeding behavior without effect on overall cardio-metabolic health. Importantly, daily replacement of VHFD also reduced measures of anxiety-like behavior in the open field test. Refining husbandry practices to include daily replacement of VHFD can therefore ensure VHFD quality and improve animal welfare. Standardizing the practice of daily VHFD replacement may also prevent experimental confound and improve experimental reproducibility and replicability.

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The Storage Conditions of High-Fat Diet Are the Key Factors for Diet-Induced Obesity and Liver Damage

Cited by 3 publications

References 31 publications

Diets, Gut Microbiota and Metabolites

Diets, Gut Microbiota and Metabolites

Microwave heating instead of blanching to produce low-fat French fries

Daily replacement of very high-fat diet stabilizes food intake and improves mouse welfare by ensuring food quality

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