The stomach in tropical sprue.

Vaish, Supriya; Sampathkumar, J; Jacob, Robert A.; Baker, Simon

doi:10.1136/gut.6.5.458

Cited by 31 publications

(10 citation statements)

References 16 publications

(12 reference statements)

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“…The results of the augmented histamine test showed a diminished acid output in patients with tropical sprue as has been observed by others (Floch et al, 1963;Vaish et al, 1965). In our patients, the significantly raised acid output observed with a suggested that low values for acid output on the augmented histamine test might at least partly be due to the lower doses of histamine administered, calculated in relation to their reduced body weights.…”

Section: Discussionsupporting

confidence: 89%

“…It is of inteiest to note that Vaish et al (1965) reported a marked increase in acid output in a patient with tropical sprue whose weight had increased by about 15 kg. between the two tests but the finding was unexplained.…”

Section: Discussionmentioning

confidence: 95%

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mentioning

confidence: 99%

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Histological and functional study of gastric mucosa in tropical sprue.

Desai¹,

Borkar²,

Jeejeebhoy³

1968

Gut

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In patients with tropical sprue studied both in Puerto Rico and South India, histological changes in gastric mucosa were noted in 67 % and 90% of patients respectively (Floch, Thomassen, Cox, and Sheehy, 1963;Vaish, Sampathkumar, Jacob, and Baker, 1965). Besides histological abnormalities, a significant reduction in gastric acid output was also observed. However, these studies did not exclude the possibility that the two conditions might be separate entities coexisting in the same population. To exclude or confirm this possibility, the incidence of chronic gastritis in patients with tropical sprue should be compared with its incidence in general hospital patients with non-specific symptoms.The purpose of this communication was to study the histology and secretory function of the gastric mucosa in healthy control subjects, patients with 'vague' gastrointestinal symptoms showing normal jejunal mucosa and absorption tests, and patients with tropical sprue from Bombay. The results showed that the incidence of chronic gastritis in patients with tropical sprue was higher than in healthy control subjects but was comparable to that in patients with vague gastrointestinal symptoms. These results suggest that chronic gastritis and tropical sprue are perhaps two unrelated conditions coexisting in the same population. MATERIAL AND METHODSCONTROL SUBJECTS (GROUP I) Thirty-six healthy adult subjects without gastrointestinal symptoms were selected for study. The subjects (who agreed to the procedure) were selected from the outpatient department and had minor symptoms which were not related to the gastrointestinal system. VAGUE GASTROINTESTINAL SYMPTOMS (GROUP i) Twentytwo adult patients with symptoms such as distension or heaviness in the abdomen after food, dull, aching orcolickyabdominal pain, vomiting, anorexia, belching, or excessive flatulence were included in this group. A detailed clinical history, physical examination and barium meal study did not show any obvious organic cause for these symptoms. In a few patients, the symptoms were probably 34 functional. All patients had a haemoglobin level of above 10 g./100 ml. Jejunal mucosa, 58Co vitamin B12 absorption, and d-xylose and faecal fat excretion were normal in all of them.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 95%

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Histological and functional study of gastric mucosa in tropical sprue.

Desai¹,

Borkar²,

Jeejeebhoy³

1968

Gut

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“…Gastric involvement consisting of atrophic or chronic gastritis, achlorhydria, or hypochlorhydria occurred in 75%, which is similar to levels in other series (Floch et al, 1963;Vaish et al, 1965;Baker and Mathan, 1971). The relatively low overall incidence of steatorrhoea (40%) is explained by the inadequate fat content of the diets early in the study.…”

Section: Discussionsupporting

confidence: 86%

Endemic tropical sprue in Rhodesia.

Thomas¹,

Clain²

1976

Gut

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SUMMARY The existence of tropical sprue in Africa is controversial. In this paper we present 31 cases seen in Rhodesia over a 15 month period. They have the clinical features, small intestinal morphology, malabsorption pattern, and treatment response of tropical sprue. Other causes of malabsorption, and primary malnutrition, have been excluded. The severity of the clinical state and intestinal malabsorption distinguish these patients from those we have described with tropical enteropathy. The previous work on tropical sprue in Africa is reviewed and it is apparent that, when it has been adequately looked for, it has been found. It is clear that the question of tropical sprue in Africa must be re-examined and that its existence may have hitherto been concealed by the assumption that primary malnutrition is responsible for the high prevalence of deficiency states.

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“…In addition, apart from these anaemic states, other patients may show recovery in acid secretion, for example, after treatment in thyrotoxicosis (Bock and Witts, 1963) and tropical sprue (Vaish, Sampathkumar, Jacob, and Baker, 1965) and also the apparently normal patient (Weir, 1967). Thus it is possible that many factors are involved in any one case.…”

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confidence: 99%