The state of functioning of working memory in schizophrenia

Salamé, Pierre; Danion, Jean-Marie; Peretti, Siegfried; Cuervo, Christine

doi:10.1016/s0920-9964(97)00107-2

Cited by 81 publications

(48 citation statements)

References 46 publications

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“…First, the patients were disproportionately slow in blocks with unmasked primes, suggesting that their pathology interferes with the filtering-out of the irrelevant primes and͞or the management of the interference that they induce. Indeed, our study comprised mostly stabilized patients with marked negative symptoms, who are known to often exhibit a general slowness in higher cognitive tasks (44). Second, surprisingly, our patients showed a significantly smaller conscious conflict effect than control subjects.…”

Section: Discussionmentioning

confidence: 82%

Conscious and subliminal conflicts in normal subjects and patients with schizophrenia: The role of the anterior cingulate

Dehaene

Artiges

Naccache

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

201

145

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The human anterior cingulate cortex (ACC), which is active during conflict-monitoring tasks, is thought to participate with prefrontal cortices in a distributed network for conscious self-regulation. This hypothesis predicts that conflict-related ACC activation should occur only when the conflicting stimuli are consciously perceived. To dissociate conflict from consciousness, we measured the behavioral and brain imaging correlates of a motor conflict induced by task-irrelevant subliminal or conscious primes. The same task was studied in normal subjects and in patients with schizophrenia in whom the ACC and prefrontal cortex are thought to be dysfunctional. Conscious, but not subliminal, conflict affected anterior cingulate activity in normal subjects. Furthermore, patients with schizophrenia, who exhibited a hypoactivation of the ACC and other frontal, temporal, hippocampal, and striatal sites, showed impaired conscious priming but normal subliminal priming. Those findings suggest that subliminal conflicts are resolved without ACC contribution and that the ACC participates in a distributed conscious control network that is altered in schizophrenia.neuroimaging ͉ priming ͉ consciousness ͉ psychiatry

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Section: Discussionmentioning

confidence: 82%

Conscious and subliminal conflicts in normal subjects and patients with schizophrenia: The role of the anterior cingulate

Dehaene

Artiges

Naccache

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

201

145

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“…Most studies of visual WM in schizophrenia examined maintenance of information concerning spatial location. 3,16,17,46,47 It is widely accepted that spatial ("where") information and nonspatial ("what") information are processed along dorsal and ventral cortical pathways, respectively, after initial processing in the stri- ate cortex, 48 and it has been suggested that these distinctions are paralleled in distinct prefrontal areas subserving WM. 49,50 Whereas other studies have reported WM impairments for nonspatial stimuli in schizophrenia, 51,52 none used a delayed matching-to-sample paradigm.…”

Section: Commentmentioning

confidence: 99%

Impairments in Perceptual Competency and Maintenance on a Visual Delayed Match-to-Sample Test in First-Episode Schizophrenia

Lencz¹,

Bilder²,

Turkel³

et al. 2003

Arch Gen Psychiatry

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“…The episodic buffer is proposed to be a storage space for temporary representations (presumably feature combinations) being entered into or retrieved from episodic longterm memory. Although several studies demonstrate impaired performance of patients with schizophrenia in tasks that tap visuo-spatial and executive components of WM (Salame et al, 1998;Keefe, 2000;Glahn et al, 2003), very little experimental work has been devoted to a direct investigation of the process of memory binding in WM and the construction of temporary episodes in on-line processing.…”

Section: Introductionmentioning

confidence: 99%

Impaired performance in a working memory binding task in patients with schizophrenia

Burglen

Marczewski

Mitchell

et al. 2004

Psychiatry Research

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This study investigated feature binding in a working memory task in patients with schizophrenia and in normal controls. Twenty-five patients and 25 controls participated. On each trial, three drawings of familiar objects were presented sequentially, each in a different cell of a 3=3 grid. In different blocks of trials, participants remembered either individual features (object and location conditions) or an object and its location (combination condition). The results showed that patients were slower and less accurate than controls under all conditions. Accuracy of both groups was reduced in the combination condition relative to the single-feature conditions, but patients showed disproportionately poorer performance in the combination condition than in the object and location conditions. Thus, patients with schizophrenia exhibit deficits in working memory, particularly when the task requires binding objects to their locations. This finding demonstrates that processes that establish coherent and temporary episodic representations in working memory are impaired in schizophrenia. ᮊ

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The state of functioning of working memory in schizophrenia

Cited by 81 publications

References 46 publications

Conscious and subliminal conflicts in normal subjects and patients with schizophrenia: The role of the anterior cingulate

Conscious and subliminal conflicts in normal subjects and patients with schizophrenia: The role of the anterior cingulate

Impairments in Perceptual Competency and Maintenance on a Visual Delayed Match-to-Sample Test in First-Episode Schizophrenia

Impaired performance in a working memory binding task in patients with schizophrenia

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