2015
DOI: 10.1161/circresaha.116.304521
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Abstract: Sudden cardiac death (SCD) from cardiac arrest is a major international public health problem accounting for an estimated 15–20% of all deaths. Although resuscitation rates are generally improving throughout the world, the majority of individuals who suffer a sudden cardiac arrest will not survive. SCD most often develops in older adults with acquired structural heart disease, but it also rarely occurs in the young, where it is more commonly due to inherited disorders. Coronary heart disease (CHD) is known to … Show more

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Cited by 498 publications
(377 citation statements)
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References 286 publications
(369 reference statements)
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“…Herein, our data show that daily administration of metformin for 14 days before CA occurs can drastically attenuate brain injury induced by CA/CPR, supporting that long‐term daily use of metformin may serve as a promising strategy to limit brain injury in CA/CPR. This intervention could be practicable in the clinical “real‐world” setting because metformin is well tolerated and safe and is routinely applied to patients with prediabetic condition, diabetes mellitus, or metabolic disorders, such as obesity, that are all conditions with increased risk for sudden CA 45. Our data indicate that long‐term metformin pretreatment appears to generate a prolonged neuroprotection against CA/CPR injury.…”
Section: Discussionmentioning
confidence: 80%
“…Herein, our data show that daily administration of metformin for 14 days before CA occurs can drastically attenuate brain injury induced by CA/CPR, supporting that long‐term daily use of metformin may serve as a promising strategy to limit brain injury in CA/CPR. This intervention could be practicable in the clinical “real‐world” setting because metformin is well tolerated and safe and is routinely applied to patients with prediabetic condition, diabetes mellitus, or metabolic disorders, such as obesity, that are all conditions with increased risk for sudden CA 45. Our data indicate that long‐term metformin pretreatment appears to generate a prolonged neuroprotection against CA/CPR injury.…”
Section: Discussionmentioning
confidence: 80%
“…Ventricular tachyarrhythmia is a common complication among patients surviving myocardial infarction (MI)1 and is the major cause of death in the United States, contributing 15% to 20% of deaths worldwide 2…”
Section: Introductionmentioning
confidence: 99%
“…Currently, there is no cure for VF, with only rudimentary treatment options available; thus, sudden cardiac death from VF remains a major worldwide health problem 3, 4. The Purkinje system is implicated in the genesis of primary VF,5, 6, 7 with radiofrequency ablation successfully treating this lethal arrhythmia by targeting triggers, such as a premature ventricular beat emanating from Purkinje tissue 7, 8, 9, 10.…”
mentioning
confidence: 99%