The societal costs of multiple sclerosis in Lebanon: a cross-sectional study

Dahham, Jalal; Hiligsmann, Mickaël; Kremer, Ingrid; Khoury, Samia J.; Darwish, Hala; Hosseini, Hassan; Evers, Silvia M. A. A.; Rizk, Rana

doi:10.1080/14737167.2023.2184802

Cited by 4 publications

(1 citation statement)

References 31 publications

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“…Studies on the burden of MS indicate that, as the severity of the disease, de ned by EDSS, increases, consumption of healthcare resources and associated costs increase, and HRQoL decreases [16,43,44]. Assessing the QoL by EDSS levels for both instruments provided an understanding of which dimensions are most affected by severity levels.…”

Section: Discussionmentioning

confidence: 99%

Health-related Quality of Life and Utilities among Lebanese Patients with Multiple Sclerosis: A cross-sectional study

Dahham

Hiligsmann

Kremer

et al. 2023

Preprint

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Objective This study assessed the Health-Related Quality of Life (HRQoL) and utilities of Multiple Sclerosis (MS) patients in Lebanon using generic and MS-specific QoL instruments, categorized by disease severity, and explored factors associated with HRQoL.Methods This was a cross-sectional, retrospective HRQoL study collecting data through face-to-face interviews using the EQ-5D-5L and the Multiple Sclerosis International Quality of Life (MusiQoL) questionnaires. We enrolled Lebanese patients aged ≥ 18 years, diagnosed with MS for > 6 months. Patients were categorized by disease severity using the expanded disability status scale (EDSS) scores: 0–3 (mild MS), 4–6.5 (moderate MS), and 7–9 (severe MS). Bivariate and linear regression analyses were performed to study factors associated with HRQoL.Results A total of 210 patients (mean age: 43.3 years; 65.7% females) were included. The mean EQ-5D-5L utility score was 0.74. This score decreased significantly with disease severity (p < 0.001 for the trend): 0.93, 0.60, and 0.32 for mild, moderate, and severe MS, respectively. The mean MusiQoL global index score was 71.33 and was significantly lower for severe MS (58.68), than for moderate (65.23) and mild (77.80), (p < 0.001 for the trend). Higher educational level, lower EDSS score, and longer disease duration were associated significantly with a higher EQ-5D-5L utility (R2 = 0.67), while employment, lower EDSS scores, and decrease in cognitive difficulties were associated with better MusiQoL utility (R2 = 0.46).Conclusions This study reveals a significant and gradual deterioration in HRQoL as MS progresses, resulting in low utility scores for patients with severe MS.

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Section: Discussionmentioning

confidence: 99%