The SLP estimation of the nanoparticle systems using size-dependent magnetic properties for the magnetic hyperthermia therapy

Synthesis and characterization of magnetite coated by maltodextrin for application in magnetic hyperthermia

“…Due to the superparamagnetic nanoparticles' characteristics, heating is caused by Ne ´el and Brown relaxation, in which, size and magnetization are determining factors for heating nanoparticles. 4 Z 1 and DC show a significant correlation. A higher Z 1 , indicating a greater amount of ferric and ferrous ion precursors in the reaction medium, corresponds to a larger average crystallite size.…”

“…It is noteworthy that the therapeutic temperature, typically between 41 and 45 1C, allows for the induction of death or apoptosis in cancer cells without affecting healthy tissue. 4,21 The heat release profiles of Fe 3 O 4 coated by maltodextrin in Fig. 5 suggest that the synthesized nanoparticles efficiently raise the temperature medium, easily reaching the therapeutic window in just 4 units, except for samples S2 and S3.…”

“…It is noteworthy that the therapeutic temperature, typically between 41 and 45 °C, allows for the induction of death or apoptosis in cancer cells without affecting healthy tissue. 4,21…”

“…[1][2][3] Treatments such as surgery, radiotherapy, and chemotherapy, while effective in many cases, come with side effects and impact the patient's quality of life. 4,5 Adaptations are being studied to make treatments more precise and less harmful, 6 along with new methods aiming to reduce exposure and treatment duration. [7][8][9] Among the new treatments are immunotherapy, 10,11 cellular therapy, 12 tissue engineering, 13 and magnetic hyperthermia.…”

“…37 It has a dense inverse spinel structure, where Fe 2+ ions occupy half of the octahedral sites, Fe 3+ ions complete the octahedral sites, and the other half occupies tetrahedral sites. Magnetite has properties such as biocompatibility, biodegradability, 9,38,39 high electrical and thermal resistance, 40,41 magnetic characteristics, 4,21 relatively high saturation magnetization, and relatively low coercivity. 42,43 With the saturation magnetization and coercivity characteristics, there may be a limitation in heating efficiency for specific loss power (SLP) since SLP is directly related to hysteresis loss.…”