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Cited by 4 publications
(2 citation statements)
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References 9 publications
(12 reference statements)
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“…Our metabolic investigations demonstrate that in addition to ensure the export of citrate from the mitochondria to the cytosol, e.g., for FA synthesis, SLC25A1 seems to be crucial for mitochondrial homeostasis and increased metabolic flexibility of the anoxia-tolerant NCI-H460 cells. Thereby our data confirm the assumption that SLC25A1 might be crucial for metabolic plasticity of cancer cells enabling adaptation and survival under adverse conditions such as nutrient starvation (glucose) or oxidative stress suggested by others ( 39 , 47 ). But our data extend the stress conditions to acute and chronic cycling severe hypoxia.…”
Section: Discussionsupporting
confidence: 91%
“…Of note, mutant p53 can promote transcriptional activation of SLC25A1 eventually by an interaction with the FOXO-1 transcription factor ( 42 ). This suggests that SLC25A1 might mediate some of the oncogenic activities of mutant p53—an important prognostic marker predictive for relapse and resistance to chemotherapy and RT ( 47 ).…”
Section: Discussionmentioning
confidence: 99%