The SLAM and SAP Gene Families Control Innate and Adaptive Immune Responses

Calpe, Silvia; Wang, Ninghai; Romero, Xavier; Berger, Scott B.; Lányi, Árpád; Engel, Pablo; Terhorst, Cox

doi:10.1016/s0065-2776(08)00004-7

Cited by 142 publications

(197 citation statements)

References 300 publications

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“…The occurrence of ITSMs in this location in other receptors has been reported, and that in LILR family members has been mentioned briefly but without further investigation (37). The adaptors SAP and EAT bind to an ITSM and can convert inhibitory to activating receptors (38,39). EAT is expressed in all peripheral macrophages and may be responsible for the activating phenotype of decidual macrophages.…”

Section: Discussionmentioning

confidence: 87%

HLA-G homodimer-induced cytokine secretion through HLA-G receptors on human decidual macrophages and natural killer cells

Houser²,

Nicotra³

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

177

150

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Human decidual CD14 ؉ macrophages and CD56 ؉ NK cells were isolated from material obtained after first-trimester pregnancy terminations. Each cell type expressed a specific surface receptor for histocompatibility leukocyte antigen (HLA)-G (an MHC class Ib protein that is expressed on extravillous trophoblasts), LILRB1 on CD14 ؉ macrophages and KIR2DL4 on CD56 ؉ NK cells. Cross-linking with anti-LILRB1 or anti-KIR2DL4 resulted in up-regulation of a small subset of mRNAs including those for IL-6, IL-8, and TNF␣ detected using a microarray representing 114 cytokines. Incubation with transfectants expressing the HLA-G homodimer (but not with transfectants expressing the HLA-G monomer) resulted in secretion of the same cytokine proteins from both leukocyte sets. Moreover, cytokine secretion from both leukocyte sets was blocked by both the appropriate anti-receptor mAb and by anti-HLA-G. The amount of these cytokines secreted by decidual macrophages was substantially greater than that secreted by decidual NK cells. VEGF was constitutively secreted by both cell types. LILRB1, which contains an immunoreceptor tyrosine-based switch motif, functions here as an activating receptor, although it has been known as an inhibitory receptor. KIR2DL4 also functions as an activating receptor, although it also has the potential to function as an inhibitory receptor. Secretion of proinflammatory and proangiogenic proteins supports a role for these leukocytes in important processes that are essential for successful pregnancy, but they may represent only a portion of the proteins that are secreted.IL-6 ͉ IL-8 ͉ pregnancy ͉ trophoblast ͉ VEGF

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Section: Discussionmentioning

confidence: 87%

HLA-G homodimer-induced cytokine secretion through HLA-G receptors on human decidual macrophages and natural killer cells

Houser²,

Nicotra³

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

177

150

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“…There is an accumulation of data demonstrating a critical role played by SLAM family receptors in immune regulation [48][49][50].…”

Section: Discussionmentioning

confidence: 99%

Altered expression of signalling lymphocyte activation molecule (SLAM) family receptors CS1 (CD319) and 2B4 (CD244) in patients with systemic lupus erythematosus

Kim¹,

Mathew²,

Patel

et al. 2010

Clinical and Experimental Immunology

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“…Receptors of the signaling lymphocyte-activation molecule family (Slamf), encoded by Slamf1-Slamf9 in the mouse, are adhesion molecules on the surface of hematopoietic cells that serve as co-stimulatory molecules which initiate distinct signal transduction networks in T cells, natural killer cells, and antigen-presenting cells (6). Additionally, our recent findings show that Slamf1 is also a microbial sensor that regulates bacterial phagosome functions in macrophages by recruiting Vps34 and Beclin-1 to the phagosome (7).…”

mentioning

confidence: 99%

Receptor Signaling Lymphocyte-activation Molecule Family 1 (Slamf1) Regulates Membrane Fusion and NADPH Oxidase 2 (NOX2) Activity by Recruiting a Beclin-1/Vps34/Ultraviolet Radiation Resistance-associated Gene (UVRAG) Complex

Wang

Detre

et al. 2012

Journal of Biological Chemistry

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Background:The receptor Slamf1 functions as a microbial sensor regulating phagocytosis. Results: Slamf1 interacts with Vps34/Beclin-1/UVRAG complex in a wide range of cells. Conclusion: Slamf1 recruits a subset of ubiquitous autophagy-associated proteins, which is involved in membrane fusion and NOX2 regulation. Significance: These studies provide insight into the regulation of microbicidal function allowing for potential therapeutic discoveries.

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The SLAM and SAP Gene Families Control Innate and Adaptive Immune Responses

Cited by 142 publications

References 300 publications

HLA-G homodimer-induced cytokine secretion through HLA-G receptors on human decidual macrophages and natural killer cells

HLA-G homodimer-induced cytokine secretion through HLA-G receptors on human decidual macrophages and natural killer cells

Altered expression of signalling lymphocyte activation molecule (SLAM) family receptors CS1 (CD319) and 2B4 (CD244) in patients with systemic lupus erythematosus

Receptor Signaling Lymphocyte-activation Molecule Family 1 (Slamf1) Regulates Membrane Fusion and NADPH Oxidase 2 (NOX2) Activity by Recruiting a Beclin-1/Vps34/Ultraviolet Radiation Resistance-associated Gene (UVRAG) Complex

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