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Cited by 33 publications
(7 citation statements)
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“…Although the infectious form of hepatitis B virus (HBV) has not been identified with certainty, the Dane particle (5), which is one ofthe particulate forms of viral antigen found in the blood of infected patients, has properties suggesting that it is HBV. The ultrastructure of the Dane particle is consistent with that of a virus (5), the antigen on its surface appears to induce HBV-neutralizing antibody (9,10), it has a unique internal core antigen (2), it is the only viral antigen form known to contain nucleic acid (20), its size (5) and usual numbers in serum (1) are consistent with the limited information about the size (12) and titer of infections HBV (4), and its concentration in the blood of infected patients appears to correlate with the frequency with which transmission of infection to patient contacts occurs (3,14).…”
mentioning
confidence: 70%
“…Although the infectious form of hepatitis B virus (HBV) has not been identified with certainty, the Dane particle (5), which is one ofthe particulate forms of viral antigen found in the blood of infected patients, has properties suggesting that it is HBV. The ultrastructure of the Dane particle is consistent with that of a virus (5), the antigen on its surface appears to induce HBV-neutralizing antibody (9,10), it has a unique internal core antigen (2), it is the only viral antigen form known to contain nucleic acid (20), its size (5) and usual numbers in serum (1) are consistent with the limited information about the size (12) and titer of infections HBV (4), and its concentration in the blood of infected patients appears to correlate with the frequency with which transmission of infection to patient contacts occurs (3,14).…”
mentioning
confidence: 70%
“…The small round particles are always the most numerous, and their concentration has been estimated as about 1012 per millilitre (Almeida, Zuckerman, Taylor, and Waterson, 1969). Although they are roughly the size expected for the serum hepatitis virus itself (McCollum, 1952) they band on ultracentrifugation in calcium chloride at a density between 1 2 and 1 29 (Barker, Smith, Gehle, and Shulman, 1969;Gerin, Purcell, Hoggan, Holland, and Chanock, 1969). This means that they cannot contain significant amounts of nucleic acid if, as would be expected from their shape, they are constructed from protein subunits according to an icosohedral pattern.…”
Section: Acute Infectionmentioning
confidence: 99%
“…Correlation with Observations on Infectivity. Mc-Collum's filtration experiments in 1952 [21] to determine the size of the serum hepatitis agent as judged by infectivity in human beings showed that the serum hepatitis agent could pass through a filter of 520 A average pore diameter. Since the particle would have to be approximately half the diameter of the filter pore, or <260 A, to permit its passage, the infectious agent is probably the size of the most abundant HAA particles.…”
mentioning
confidence: 99%
“…By titering infectious plasma in experimental subjects, Murray [22] estimated the concentration of infectious particles in serum from patients with serum [7,9,11,21] N ucleotide content [16] Stability [9,11,12,14,20] Protein-like characteristics [12] Distribution of HAA in Cohn ethanol fractionations of highly contaminated plasma [24] Total 379 27 383 67 54 59 NOTE: The clinical differentiation of infectious and serum hepatitis in these cases (except for those caused by MS-1 and MS-2) was based chiefly on incubation period after the implicated parenteral exposure, short-incubation (two to six weeks) being called infectious hepatitis, long-incubation (six to twenty-six weeks) serum hepatitis. Most cases in which there was no parenteral exposure were considered to be infectious hepatitis, and some were not differentiated.…”
mentioning
confidence: 99%