The Significane and Value of Uranium in Urine Analysis

Butterworth, A.

doi:10.1093/occmed/5.2.36

Cited by 4 publications

(3 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Glucose was not elevated in any of the patients. • Another case of dermal exposure to hot uranium nitrate was reported by Butterworth (1955). The calculated peak concentration of uranium was about 3 g U g Ϫ1 kidney and occurred about 9 d after the accident.…”

Section: Overview Of Human Casesmentioning

confidence: 96%

See 1 more Smart Citation

Assessing the Renal Toxicity of Capstone Depleted Uranium Oxides and Other Uranium Compounds

Roszell¹,

Hahn

Lee³

et al. 2009

Health Physics

View full text Add to dashboard Cite

The primary target for uranium toxicity is the kidney. The most frequently used guideline for uranium kidney burdens is the International Commission on Radiological Protection value of 3 microg U g(-1) kidney, a value that is based largely upon chronic studies in animals. In the present effort, a risk model equation was developed to assess potential outcomes of acute uranium exposure. Twenty-seven previously published case studies in which workers were acutely exposed to soluble compounds of uranium (as a result of workplace accidents) were analyzed. Kidney burdens of uranium for these individuals were determined based on uranium in the urine, and correlated with health effects observed over a period of up to 38 years. Based upon the severity of health effects, each individual was assigned a score (- to +++) and then placed into a Renal Effects Group (REG). A discriminant analysis was used to build a model equation to predict the REG based on the amount of uranium in the kidneys. The model equation was able to predict the REG with 85% accuracy. The risk model was used to predict the REG for soldiers exposed to depleted uranium as a result of friendly fire incidents during the 1991 Gulf War. This model equation can also be used to predict the REG of new cases in which acute exposures to uranium have occurred.

show abstract

Section: Overview Of Human Casesmentioning

confidence: 96%

“…• An experiment in which a healthy volunteer ingested 1 g of uranyl nitrate to help establish excretion rates was reported by Butterworth (1955). The person experienced vomiting, diarrhea, and albuminuria.…”

Section: Overview Of Human Casesmentioning

confidence: 99%

Assessing the Renal Toxicity of Capstone Depleted Uranium Oxides and Other Uranium Compounds

Roszell¹,

Hahn

Lee³

et al. 2009

Health Physics

View full text Add to dashboard Cite

show abstract

“…Also, Butterworth (1955) reported a case of voluntary experimental ingestion of 470 mg of uranium as uranyl nitrate by a male subject, with complete recovery from minor renal effects within 24 h.…”

Section: Establishment Of Level For Irreversible or Serious Long Lastmentioning

confidence: 99%

Proposed Standards for Acute Exposure to Low Enrichment Uranium for Compliance with 10 CFR 70.61

Kathren

Burklin²

2008

Health Physics

View full text Add to dashboard Cite

Title 10, Code of Federal Regulations Part 70, puts forth requirements for licensure of special nuclear material including specific risk criteria for acute intakes based on biological effects. Standards for acute oral and inhalation intakes of soluble low enrichment are proposed for the three levels of biological effects given in the regulations. These levels were developed largely from available human data and have a large measure of conservatism. The proposed threshold for life endangerment was 500 mg for acute inhalation intakes and 2,500 mg for acute ingestion intakes. Acute intakes of 1,400 mg for ingestion and 100 mg for inhalation are proposed as thresholds for irreversible or serious long lasting health effects. For minor transient health effects, the proposed levels are 410 and 30 mg, respectively, for acute ingestion and inhalation intakes. For acute intakes below these levels, no demonstrable toxicological effects are anticipated.

show abstract

Annex D: absorption and retention of radionuclides

Paquet¹,

Harrison

2006

Ann ICRP

View full text Add to dashboard Cite

The Significane and Value of Uranium in Urine Analysis

Cited by 4 publications

References 1 publication

Assessing the Renal Toxicity of Capstone Depleted Uranium Oxides and Other Uranium Compounds

Assessing the Renal Toxicity of Capstone Depleted Uranium Oxides and Other Uranium Compounds

Proposed Standards for Acute Exposure to Low Enrichment Uranium for Compliance with 10 CFR 70.61

Annex D: absorption and retention of radionuclides

Contact Info

Product

Resources

About