The significance of uric acid in the diagnosis and treatment of Parkinson disease

Yu, Zhange; Zhang, Shuai; Wang, Dongdong; Fan, Meng; Gao, Fuqiang; Sun, Wei; Li, Zirong; Li, Shiliang

doi:10.1097/md.0000000000008502

Cited by 42 publications

(43 citation statements)

References 75 publications

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“…B). A sex difference of the UA levels in PD has been also reported in several epidemiological studies . This discrepancy might be caused by sex hormones, age, and environmental and/or genetic factors.…”

Section: Discussionmentioning

confidence: 62%

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Nonmercaptalbumin as an oxidative stress marker in Parkinson’s and PARK2 disease

Ueno

Hatano

Okuzumi

et al. 2020

Ann Clin Transl Neurol

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Objective To investigate the oxidized albumin ratio, which is the redox ratio of human nonmercaptalbumin (HNA) to serum albumin (%HNA), as a biomarker in idiopathic Parkinson’s disease (iPD) and related neurodegenerative disorders. Methods This prospective study enrolled 216 iPD patients, 15 patients with autosomal recessive familial PD due to parkin mutations (PARK2), 30 multiple system atrophy (MSA) patients, 32 progressive nuclear palsy (PSP) patients, and 143 healthy controls. HNA was analyzed using modified high‐performance liquid chromatography and was evaluated alongside other parameters. Results iPD and PARK2 patients had a higher %HNA than controls (iPD vs. controls: odds ratio (OR) 1.325, P < 0.001; PARK2 vs. controls: OR 1.712, P < 0.001). Even iPD patients at an early Hoehn & Yahr stage (I and II) showed a higher %HNA than controls. iPD patients had a higher %HNA than MSA and PSP patients (iPD vs. MSA: OR 1.249, P < 0.001, iPD vs. PSP: OR 1.288, P < 0.05). When discriminating iPD patients from controls, %HNA corrected by age achieved an AUC of 0.750; when discriminating iPD patients from MSA and PSP patients, an AUC of 0.747 was achieved. Furthermore, uric acid, an antioxidant compound, was decreased in iPD patients, similar to the change in %HNA. Interpretation %HNA was significantly increased in iPD and PARK2 patients compared with controls, regardless of disease course and severity. Oxidative stress might be increased from the early stages of iPD and PARK2 and play an important role in their pathomechanisms.

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Section: Discussionmentioning

confidence: 62%

“…A sex difference of the UA levels in PD has been also reported in several epidemiological studies. [29][30][31] This discrepancy might be caused by sex hormones, age, and environmental and/or genetic factors. Additionally, UA plays a direct role in antioxidation, whereas oxidative albumin results from oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Nonmercaptalbumin as an oxidative stress marker in Parkinson’s and PARK2 disease

Ueno

Hatano

Okuzumi

et al. 2020

Ann Clin Transl Neurol

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“…The loss and degeneration of dopaminergic neurons translates into a significant deficiency of dopaminergic transmission and associated neurological disorders (motor and mental retardation, resting tremor, muscle stiffness). Intravital diagnosis of Parkinson's disease is based on clinical symptoms and neurological differential diagnosis, which in the early stages of disease is difficult and in the advanced phase does not translate into any therapeutic benefits [4]. Degeneration and loss of dopaminergic neurons is a progressive process, with no effective treatment so far.…”

Section: Pathogenesis Of Parkinson's Diseasementioning

confidence: 99%

“…The aetiopathogenesis of PD also highlights the shortage of physiological antioxidants and free radical scavengers, as demonstrated for uric acid [4].…”

Section: Pathogenesis Of Parkinson's Diseasementioning

confidence: 99%

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Odd correlation: Parkinson’s disease and melanoma. What is the possible link?

2019

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Parkinson's disease (PD) is a neurodegenerative disorder, characterised by depletion of dopamine in the striatum and loss of melanin-positive, dopaminergic neurons in the substantia nigra. Melanoma is a skin neoplasm arising from epidermal melanocytes. The epidemiology of melanoma focuses on well-known risk factors such as light skin and hair colour, gender, eye pigmentation, and ultraviolet (UV) exposure. Many studies have suggested an association between Parkinson's disease and melanoma. The mechanism underlying the possible connection between PD and melanoma is not clear and has aroused lots of interest. More interesting is that the link between these two diseases runs both ways. What is the underlying cause of this reciprocal association?Is it due to Parkinson's treatment? Is levodopa the reason for increased incidence of melanoma in people with the neurodegenerative condition? Are there any genetic, immune system irregularities or environmental risk factors that serve as the common denominator between these two conditions? Should we consider melanoma comorbidity with Parkinson's disease and vice versa? Some hypotheses include pigmentation changes in melanin and/or melanin synthesis enzyme like tyrosinase hydroxylase, autophagy deficits, disturbed form of metabolically controlled cell death, and changes of PD-related genes such as Parkin or a-synuclein. Learning more about the relationship between PD and melanoma may lead to a better understanding of each disease and contribute to more effective treatments of both.

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Dietary Antioxidants and Risk of Parkinson's Disease in the Singapore Chinese Health Study

Ying

Khan

et al. 2020

Movement Disorders

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A BS TRACT: Background: Despite experimental evidence implicating oxidative stress in the pathogenesis of PD, epidemiological studies have provided inconsistent associations between dietary antioxidants and risk of developing PD. Furthermore, no study has been done in any Asian population. Objectives: We examined the associations for intake levels of dietary carotenoids (α-carotene, β-carotene, lycopene, β-cryptoxanthin, and lutein) and vitamins (vitamin A, C and E) and the risk of developing PD. Methods: We used data from the Singapore Chinese Health Study, a population-based prospective cohort of 63,257 men and women aged 45 to 74 years during enrollment in 1993-1998. Antioxidant intake was derived from a validated semiquantitative food frequency questionnaire. Incident cases were identified through followup interviews, hospital records, or PD registries through 31 July 2018. Hazard ratios and corresponding 95% confidence intervals were derived from multivariable Cox proportional hazard regression models with adjustment for other lifestyle and dietary factors. Results: During an average 19.4 years of follow-up, 544 incident PD cases were identified. No association was found for dietary carotenoids, individually or summed. Hazard ratio comparing highest to lowest quartile for total carotenoids was 0.98 (95% confidence interval: 0.76-1.28; P trend = 0.83). There were also no clear dose-dependent associations of dietary vitamins A, C, and E with risk of developing PD (all P trend ≥ 0.10). Sensitive analyses with lag time and excluding supplement use did not materially alter results. Conclusions: Intake of dietary antioxidants, such as carotenoids and vitamins, was not associated with the risk of developing PD in Singaporean Chinese.

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The significance of uric acid in the diagnosis and treatment of Parkinson disease

Cited by 42 publications

References 75 publications

Nonmercaptalbumin as an oxidative stress marker in Parkinson’s and PARK2 disease

Nonmercaptalbumin as an oxidative stress marker in Parkinson’s and PARK2 disease

Odd correlation: Parkinson’s disease and melanoma. What is the possible link?

Dietary Antioxidants and Risk of Parkinson's Disease in the Singapore Chinese Health Study

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