2006
DOI: 10.1177/1533317506289282 View full text |Buy / Rent full text
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Abstract: Mild cognitive impairment (MCI) represents a transition between normal aging and Alzheimer's disease (AD). The aim of this study was to investigate the predictive value of vitamin B12/folate, homocysteine, standard laboratory parameters, and concomitant diseases for development of AD in persons with an MCI diagnosis. Development of dementia was followed for 6 years in 93 consecutively recruited MCI persons. Information concerning the above factors was obtained from medical journals. Thirty-four percent of part… Show more

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“…Results for other nutrients studied (antioxidants, dietary patterns, multivitamins) are not presented here. Of the 33 included papers, 19 were cohort studies including 11 on folate, other B-group vitamins and/or homocysteine [26][27][28][29][30][31][32][33][34][35][36] and eight on fish, DHA or EPA [37][38][39][40][41][42][43][44]. The remaining 14 were randomized controlled trials (RCTs) including ten on folic acid with or without other B-group vitamins [45][46][47][48][49][50][51][52][53][54], and four on mixed fatty acids [55][56][57][58].…”
Section: Overall Search Findingsmentioning
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“…Results for other nutrients studied (antioxidants, dietary patterns, multivitamins) are not presented here. Of the 33 included papers, 19 were cohort studies including 11 on folate, other B-group vitamins and/or homocysteine [26][27][28][29][30][31][32][33][34][35][36] and eight on fish, DHA or EPA [37][38][39][40][41][42][43][44]. The remaining 14 were randomized controlled trials (RCTs) including ten on folic acid with or without other B-group vitamins [45][46][47][48][49][50][51][52][53][54], and four on mixed fatty acids [55][56][57][58].…”
Section: Overall Search Findingsmentioning
“…Ten cohort studies (Table 1) evaluated the association of folate and other B-vitamins in cognitively intact or impaired aging participants with incident AD or dementia over a 3-9 year follow-up period [26][27][28][30][31][32][33][34][35][36]. Only one study considered folate only [31], nine included vitamin B-12 [26][27][28]30,[32][33][34][35][36] and four included vitamin B-6 [27,30,32,35] in their assessment.…”
Section: Folate and Other B-vitaminsmentioning
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