The Significance of Peritoneal Cytology in Uterine Cervix and Endometrial Cancer

Prognostic significance of positive peritoneal cytology in endometrial carcinoma confined to the uterus

“…Based on studies that found that positive cytology is an independent adverse prognostic factor (Harouny et al, 1988;Mazurka et al, 1988;Brewington et al, 1989;Turner et al, 1989;Sutton, 1990;Morrow et al, 1991;Grigsby et al, 1992;Kadar et al, 1994;Descamps et al, 1997;Kashimura et al, 1997;Obermair et al, 2001), postoperative adjuvant therapy was recommended for patients with positive peritoneal cytology. Progestins, whole abdominal external radiation, intraperitoneal radioactive chromic phosphate ( 32 P), and multiagent chemotherapy have been proposed.…”

Impact of positive peritoneal cytology on prognosis in patients with cervical cancer: A meta-analysis

“…Figure 1 presents a flow diagram showing how relevant studies were identified. A total of 22 potentially relevant papers were found by focusing on abnormal peritoneal cytology and prognosis, particularly recurrence or lymph node metastasis (Creasman and Rutledge, 1971;Keettel et al, 1974;Hughes et al, 1980;Abu-Ghazaleh et al, 1984;Kilgore et al, 1984;Ziselman et al, 1984;Willett, 1985;Roberts et al, 1986;Imachi et al, 1987;Delgado et al, 1989;Zuna et al, 1990;Ito and Noda, 1992;Morris et al, 1992;Patsner, 1992;Trelford et al, 1995;Zuna and Behrens, 1996;Kashimura et al, 1997;Takeshima et al, 1997;Estape et al, 1998;Kasamatsu et al, 2009;Kuji et al, 2014). Among these 22 papers, 16 were excluded: seven papers were incomplete studies providing no exact recurrence data (Abu-Ghazaleh et al, 1984;Kilgore et al, 1984;Zuna et al, 1990;Morris et al, 1992;Patsner, 1992;Trelford et al, 1995;Estape et al, 1998), one paper was a letter to the editor , and another five studies lacked relevance to prognosis and cervical cancer (Creasman and Rutledge, 1971;Hughes et al, 1980;Ziselman et al, 1984;Willett, 1985;Zuna and Behrens, 1996); three studies included patients who underwent surgical treatment at advanced stages (Keettel et al, 1974;Roberts et a...…”

“…Among these 22 papers, 16 were excluded: seven papers were incomplete studies providing no exact recurrence data (Abu-Ghazaleh et al, 1984;Kilgore et al, 1984;Zuna et al, 1990;Morris et al, 1992;Patsner, 1992;Trelford et al, 1995;Estape et al, 1998), one paper was a letter to the editor , and another five studies lacked relevance to prognosis and cervical cancer (Creasman and Rutledge, 1971;Hughes et al, 1980;Ziselman et al, 1984;Willett, 1985;Zuna and Behrens, 1996); three studies included patients who underwent surgical treatment at advanced stages (Keettel et al, 1974;Roberts et al, 1986;Imachi et al, 1987). The remaining six studies reported on abnormal peritoneal cytology and prognosis and, thus, were included in the meta-analysis (Delgado et al, 1989;Ito and Noda, 1992;Kashimura et al, 1997;Takeshima et al, 1997;Kasamatsu et al, 2009;Kuji et al, 2014).…”

“…Positive peritoneal cytology in cervical cancer with ADC plus SCC histological type was also associated with lymph node metastasis (OR: 7.024; 95% CI: 2.422-20.368; Po0.001 and I 2 ¼ 0%). As for the SCC histological type, there were two studies (OR: 4.224; 95% CI: 1.343-13.288; P ¼ 0.014 and I 2 ¼ 0%) ( Figure 4B) (Delgado et al, 1989;Kashimura et al, 1997).…”

“…Previous reports have been inconsistent; whereas one study failed to show any prognostic inference of positive peritoneal cytology in cervical cancer (Abu-Ghazaleh et al, 1984;Delgado et al, 1989;Trelford et al, 1995;Takeshima et al, 1997), other studies reported that patients with positive peritoneal cytology have a poor prognosis than those with negative cytology (Imachi et al, 1987;Ito and Noda, 1992;Kashimura et al, 1997;Estape et al, 1998;Zuna et al, 2009). Furthermore, some studies reported that positive peritoneal cytology was associated with poor prognosis only in the patients with ADC or adenosquamous carcinoma, but not in those with SCC (Kasamatsu et al, 2009;Kuji et al, 2014).…”