2020
DOI: 10.3390/ijms22010320
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Abstract: Adenosine acts as an endogenous anticonvulsant and seizure terminator in the brain. Many of its anticonvulsive effects are mediated through the activation of the adenosine A1 receptor, a G protein-coupled receptor with a wide array of targets. Activating A1 receptors is an effective approach to suppress seizures. This review gives an overview of the neuronal targets of the adenosine A1 receptor focusing in particular on signaling pathways resulting in neuronal inhibition. These include direct interactions of G… Show more

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Cited by 4 publications
(4 citation statements)
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References 194 publications
(243 reference statements)
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“…The transcription factor NF kB regulates the expression of anti apoptotic proteins [14]. TRADD mediated degradation of the NF kB IkB complex allows the NF kB p65 isoform to translocate into the nucleus, where it regulates the transcription of a wide range of genes responsible for the synthesis of proteins, such as Bcl 2, IL 6, IL 8, and VEGF, which are involved in cell sur vival [25].…”
Section: Resultsmentioning
confidence: 99%
“…Some studies have reported the association of the nuclear factor NF kB, a master regulator of the inflammatory response, with epilepsy in ani mals [14]. NF kB consists of two subunits, and its most common form is the p65/p50 heterodimer, which typically exists in the cytoplasm in a form inhibited by the IkB protein.…”
Section: Introductionmentioning
confidence: 99%
“…Presynaptically, voltage-gated Ca 2+ channels are inhibited, resulting in reduced neurotransmitter release. Postsynaptically, G protein-mediated inwardly rectifying potassium channels are activated, resulting in membrane hyperpolarization [ 4 , 5 , 6 ].…”
Section: Introductionmentioning
confidence: 99%
“…This further leads to the inhibition of the glutamate release from the nerve terminals (Kosmowska et al 2020). Similarly, the postsynaptic hyperpolarization by A1 receptors occurred by activation of G-protein coupled inwardly-rectifying potassium channels that lower the hyperexcitability of neurons at postsynaptic terminals (Hill et al 2020, Spanoghe et al 2021.…”
Section: Introductionmentioning
confidence: 99%