2016
DOI: 10.18632/aging.100893
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Abstract: Abstract:In spite of great efforts, the mechanisms for postovulatory oocyte aging are not fully understood. Although our previous work showed that the FasL/Fas signaling facilitated oocyte aging, the intra-oocyte signaling pathways are unknown. Furthermore, the mechanisms by which oxidative stress facilitates oocyte aging and the causal relationship between Ca 2+ rises and caspase-3 activation and between the cell cycle and apoptosis during oocyte aging need detailed investigations. Our aim was to address thes… Show more

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Cited by 17 publications
(15 citation statements)
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References 48 publications
(66 reference statements)
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“…Calcium is a major signaling molecule that regulates many aspects of cellular function, including cell‐cycle progression (Machaty, ; Tosti, ), cell‐cycle arrest (Tripathi et al, ), and apoptosis (Berridge et al, ; Tiwari et al, ). A sustained increase in [Ca 2+ ] i levels beyond the normal physiologic range in oocytes triggers FAS‐ligand‐ and mitochondria‐mediated apoptosis in several mammalian species (Tiwari, Prasad, Shrivastav, & Chaube, ; Zhu et al, ). Previous studies suggested that the physiological role of calcium depends on its intracellular concentration (Homa, ; Naik & Pardasani, ; Tosti, ; Whitaker, ), resulting in improved developmental competence or fragmentation/apoptosis (Takahashi et al, ; Takahashi, Saito, Hiroi, Doi, & Takahashi, ).…”
Section: Discussionmentioning
confidence: 99%
“…Calcium is a major signaling molecule that regulates many aspects of cellular function, including cell‐cycle progression (Machaty, ; Tosti, ), cell‐cycle arrest (Tripathi et al, ), and apoptosis (Berridge et al, ; Tiwari et al, ). A sustained increase in [Ca 2+ ] i levels beyond the normal physiologic range in oocytes triggers FAS‐ligand‐ and mitochondria‐mediated apoptosis in several mammalian species (Tiwari, Prasad, Shrivastav, & Chaube, ; Zhu et al, ). Previous studies suggested that the physiological role of calcium depends on its intracellular concentration (Homa, ; Naik & Pardasani, ; Tosti, ; Whitaker, ), resulting in improved developmental competence or fragmentation/apoptosis (Takahashi et al, ; Takahashi, Saito, Hiroi, Doi, & Takahashi, ).…”
Section: Discussionmentioning
confidence: 99%
“…These studies suggest that high level of [Ca ++ ]i trigger generation of ROS and mitochondria‐mediated apoptosis in mammalian oocytes. The involvement of increased [Ca ++ ]i level has also been reported to trigger Fas ligand‐mediated apoptosis in mouse oocytes (Zhu et al, ).…”
Section: Role Of Ca++ In Meiotic Resumption From Diplotene Arrestmentioning
confidence: 99%
“…Growing body of evidences suggest that sustained high cytosolic free Ca ++ level induces CaMKII activity (Olofsson et al, ; Zhu et al, ) and trigger generation of ROS (Tripathi and Chaube, ) sufficient enough to cause oxidative stress (OS) in aged oocytes cultured in vitro (Gordo et al, ; Chaube et al, ; Martin‐Romero et al, ; Tripathi and Chaube, ). Further, CaMKII activates Wee 1 that induces Thr14/Tyr15 phosphorylation of Cdk1 and cyclin B1 degradation leading to MPF destabilization (Kubiak et al, ; Oh, ).…”
Section: Role Of Ca++ In Meiotic Resumption From Diplotene Arrestmentioning
confidence: 99%
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