“…23,24 Rsk family kinases have multiple cellular functions. They are involved in the phosphorylation of histone H3 and remodeling of chromatin in response to epidermal growth factor (EGF) 25 and can regulate gene expression by phosphorylating transcription factors, including c-Fos, 26,27 cAMP-response element-binding protein (CREB), [28][29][30] CREB-binding protein, 31,32 estrogen receptor, 33 ATF4,34 NFATc4, 35 and NF-B/I B␣. 36,37 p90 Rsk2 was also reported to phosphorylate the p34 cdc2 inhibitory kinase Myt1 in frog oocytes, leading to activation of the cyclin-dependent kinase p34 cdc2 that then promotes cell-cycle progression of oocytes through the G2/M phase of meiosis.…”