The Short Child with Subnormal Plasma Somatomedin C

Rudman, Daniel; Kutner, Michael; Chawla, Rajender K.

doi:10.1203/00006450-198510000-00001

Cited by 25 publications

(8 citation statements)

References 7 publications

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“…Plasma IGF-1 levels are low in classic GH deficiency (30) and sometimes in "short normal" children (31). In our previous study, we did not find impairment of 24-hour GH secretion in a group of 12 JRA patients compared with "short normal" children (1).…”

Section: Discussionmentioning

confidence: 82%

Juvenile rheumatoid arthritis. Effects of disease activity and recombinant human growth hormone on insulin‐like growth factor 1, insulin‐like growth factor binding proteins 1 and 3, and osteocalcin

Davies

Sandoval

Reeve

et al. 1997

Arthritis & Rheumatism

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Objective. To investigate possible mechanisms of growth impairment in children with juvenile rheumatoid arthritis (JRA). Methods.Eighteen prepubertal children with JRA and growth retardation received recombinant human growth hormone (rHuGH) for 1 year. Growth hormone profiles over 24 hours were obtained before treatment in 12 patients; the levels did not differ from those in "short normal" children. Levels of insulin-like growth factor 1 (IGF-1), IGF binding proteins (IGFBPs) 1 and 3, insulin, osteocalcin, and C-reactive protein (CRF'), as well as the erythrocyte sedimentation rate were measured serially. Pretreatment levels were compared with control levels.Results. In JRA patients, IGF-1, IGFBP-3, and osteocalcin levels were significantly lower and insulin levels significantly higher than those in controls, but there was no significant difference in the level of IGFBP-1. With rHuGH treatment, height velocity and mean levels of IGF-1, osteocalcin, and insulin increased

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Section: Discussionmentioning

confidence: 82%

Juvenile rheumatoid arthritis. Effects of disease activity and recombinant human growth hormone on insulin‐like growth factor 1, insulin‐like growth factor binding proteins 1 and 3, and osteocalcin

Davies

Sandoval

Reeve

et al. 1997

Arthritis & Rheumatism

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“…Their clinical characteristics are summarized in Table 2 of the preceding report (1). Mean serum immunoreactive GH2 response to L-dopa or glucagon was > 12 ng/ml, showing normal immunoreactive GH status.…”

Section: Subjectsmentioning

confidence: 99%

“…The hyposomatomedinemic, non-GHD, short (less than third percentile) children consisted of 10 boys and three girls, 7 to 10 yr of age, who had been identified during phase 2 of a preceding study (1). Their clinical characteristics are summarized in Table 2 of the preceding report (1).…”

Section: Subjectsmentioning

confidence: 99%

Heterogeneity of Growth Hormone in the Nocturnal Serum of Children

1985

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ABSTRACT. The nocturnal serum of 13 nongrowth hormone deficient, hyposomatomedinemic short children and of 12 normal children of average height was analyzed by both polyclonal and biclonal radioimmunoassays. The biclonal/polyclonal ratio for immunochemical grade human growth hormone was 1.0, but for the nocturnal sera in both groups, this ratio was significantly less than 1.0 (range 0.5-1.2, average 0.7-0.8). The ratio did not differ significantly between the two groups of children. (Pediatr Res 19: 981-985,1985) Abbreviations RIA, radioimmunoassay GH, growth hormone hPL, human placental lactogen hPRL, human prolactin hTSH, human thyroid-stimulating hormone hFSH, human follicle-stimulating hormone hLH, human luteinizing hormone hGH, human growth hormone RRA, radioreceptor assayThe purpose of this study was to compare the RIA profile of the endogenous GH between normal children of average height and hyposomatomedinemic non-GHD, short children identified in a preceding investigation (I) by means of newly available monoclonal RIA techniques (2) together with the conventional polyclonal assay (3). The gel-filtration behavior of the serum GH also was compared between the two groups of children. METHODS SUBJECTSThe normal group comprised six boys and six girls, 12 to 18 yr old, between the 5th and 95th percentiles in height. History and physical examination revealed no evidence of acute or chronic illness.The hyposomatomedinemic, non-GHD, short (less than third percentile) children consisted of 10 boys and three girls, 7 to 10 yr of age, who had been identified during phase 2 of a preceding study (1). Their clinical characteristics are summarized in Table 2 of the preceding report (1). Mean serum immunoreactive GH2 response to L-dopa or glucagon was > 12 ng/ml, showing normal immunoreactive GH status. STUDY DESIGNThe children were hospitalized for 5 days. They received no medications. The short children had not received hGH injections during the previous month. Their diet was 2300 calories, 100 g protein, 250 g carbohydrate, and 100 g fat. Via an inwelling heparin lock inserted at 2000-2 100,5 ml heparinized blood were removed on retiring, and at 30, 60, 90, and 120 min after sleep began. The blood was kept at 4" C until 800, when it was spun; the serum was stored at -20" C for up to 2 wk before analysis by RIA (4). Some sera also were examined by gel filtration. MATERIALSThe kits were obtained from Kallestad Laboratories (New York, NY) ("polyclonal kit") and from Hybritech Laboratories (Los Angeles, CA) ("biclonal kit"). Two mouse monoclonal antibodies (33.2 and 101.3) to hGH were purchased from Hybritech. According to the manufacturers, the antibodies were directed at different epitopes of the hGH molecule. The precipitating antibody (rabbit antiserum to mouse IgG) was obtained from Calbiochem-Behring (Los Angeles, CA). The labeled hGH used in the monoclonal assays was obtained from Kallestad Laboratories. Immunochemical grade hGH, used as the cold hormone in these assays, was from National Institutes of Health,...

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“…After an overnight fast, blood was drawn for anal ysis of plasma SmC by radioimmunoassay, which was done at Nichols Institute, Los Angeles, Calif. Techni cal details of the procedure were given in an earlier report [25]. The intraassay and intraindividual (dayto-day) coefficients of variation were 4 and 12%, respectively [26]. The plasma SmC level of healthy men aged 26-45. determined at Nichols Institute, was 0.73 ± 0.23 units/ml (mean ± SD).…”

Section: Methods and Patientsmentioning

confidence: 99%

Hyposomatomedinemia in the Men of a Veterans Administration Nursing Home: Prevalence and Correlates

Rudman¹,

Nagraj²,

Mattson³

et al. 1987

Gerontology

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A previous study found hyposomatomedinemia to be common in the men of this VA Nursing Home. To gain information on the prevalence and correlates of this endocrine characteristic, we have measured plasma somatomedin C (SmC) in 69 Nursing Home men 55–95 years old (group I), and in 37 independent men 56–87 years old attending our geriatric medicine outpatient clinic (group II). In groups I and II, a clinical data base was compiled comprising: blood chemistries, measures of body composition – nutritional state and functional level, diagnoses, medications, and morbidity and mortality during the year after the SmC analysis. The mean ± SD for SmC was significantly (p < 0.05) lower in group I (0.35 ± 0.21 units/ml) than in group II (0.45 ± 0.13 units/ml). SmC less than 0.25 units/ml, a range consistent with severe growth hormone deficiency, was found almost exclusively in group I (31.8% of men in group I, 3.7% of men in group II). In either group I, or in groups I and II combined, SmC was significantly (p < 0.05) correlated with body weight as percentage of ideal, midarm muscle circumference (MAMC) as percent of standard, diagnosis of cerebrovascular disease, and plasma testosterone level. Men with SmC values below 0.25 units/ml had significantly (p < 0.05) lower values for body weight as percentage of ideal, and for MAMC as percentage of standard. Except for cerebrovascular disease, SmC did not correlate significantly (p > 0.05) with diagnosis, drugs, morbidity or mortality.

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The Short Child with Subnormal Plasma Somatomedin C

Cited by 25 publications

References 7 publications

Juvenile rheumatoid arthritis. Effects of disease activity and recombinant human growth hormone on insulin‐like growth factor 1, insulin‐like growth factor binding proteins 1 and 3, and osteocalcin

Juvenile rheumatoid arthritis. Effects of disease activity and recombinant human growth hormone on insulin‐like growth factor 1, insulin‐like growth factor binding proteins 1 and 3, and osteocalcin

Heterogeneity of Growth Hormone in the Nocturnal Serum of Children

Hyposomatomedinemia in the Men of a Veterans Administration Nursing Home: Prevalence and Correlates

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