The sFlt-1/PlGF ratio as a triage tool to identify superimposed preeclampsia in women with chronic hypertension in emergency rooms

Hernández-Pacheco, José Antonio; Rosales-Zamudio, Claudia Ivet; Borboa-Olivares, Héctor; Espejel-Núñez, Aurora; Parra-Hernández, Sandra; Estrada-Gutiérrez, Guadalupe; Camargo-Marín, Lisbeth; Medina-Bastidas, Diana; Guzmán-Huerta, Mario

doi:10.1016/j.preghy.2020.04.014

Cited by 14 publications

(11 citation statements)

References 13 publications

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“…As a result, research on chronic hypertension and the competing risks model was focused on, along with studies on preeclampsia from lowered risks and the pathogenetic function. Researchers have been working on the chronic hypertension (Banala et al, 2020;Bramham et al, 2020;Hernández-Pacheco et al, 2020) as well as the competing risks model (Larroca et al, 2014;O'Gorman et al, 2016;Tsiakkas et al, 2016) in recent years.…”

Section: Discussionmentioning

confidence: 99%

A bibliometric review of 35 years of studies about preeclampsia

Akbari

Hantoushzadeh²,

Panahi³

et al. 2023

Front. Physiol.

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The purpose of this study is to investigate preeclampsia. It used the visualization tools of CiteSpace, VOSviewer, Gunnmap, Bibliometrix®, and Carrot2 to analyze 3,754 preeclampsia studies from 1985 to 2020 in Obstetrics and Gynecology areas. Carrot2 was used to explain each cluster in extra detail. The results found that there is an increasing trend in many publications related to preeclampsia from 1985 to 2020. The number of studies on preeclampsia has increased significantly in the last century. Analysis of the keywords found a strong relationship with preeclampsia concepts and keywords classified into five categories. Co-citation analysis was also performed which was classified into six categories. Reading the article offers important to support not only to grind the context of preeclampsia challenges but also to design a new trend in this field. The number of studies on preeclampsia has substantially improved over the decades ago. The findings of documents published from 1985 to 2020 showed three stages in research on this subject: 1985 to 1997 (a seeding stage), 1997–2005 (rapid growth stage), and 2005 onwards (development stage).

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Section: Discussionmentioning

confidence: 99%

A bibliometric review of 35 years of studies about preeclampsia

Akbari

Hantoushzadeh²,

Panahi³

et al. 2023

Front. Physiol.

View full text Add to dashboard Cite

show abstract

“…Recently, the utility of the sFlt-1/PlGF ratio for the differential diagnosis of superimposed PE was evaluated in a small cohort study of 42 women with chronic hypertension. According to this study by Hernandez-Pacheco et al 17 , the sFlt-1/PlGF ratio was useful for triaging women with chronic hypertension and differentiating between superimposed PE and uncontrolled hypertension. However, the predictive accuracy was not reported, and prespecified cut-off points were not described.…”

Section: Interpretation Of Study Findings and Comparison With Existin...mentioning

confidence: 98%

Should angiogenic markers be included in diagnostic criteria of superimposed pre‐eclampsia in women with chronic hypertension?

Binder

Kalafat

Palmrich

et al. 2022

Ultrasound in Obstet & Gyne

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What are the novel findings of this work?In pregnant women with chronic hypertension and suspected superimposed pre-eclampsia (PE), addition of angiogenic markers to the conventional diagnostic criteria for superimposed PE proposed by the International Society for the Study of Hypertension in Pregnancy (ISSHP) improves the detection rate of both maternal and perinatal adverse outcomes and increases the positive and negative predictive values for adverse maternal outcome. What are the clinical implications of this work?This study demonstrates the clinical usefulness of angiogenic marker assessment in women with chronic hypertension and suspected superimposed PE and proposes its inclusion as a diagnostic criterion for superimposed PE. The routine use of angiogenic markers should be considered in guidelines on chronic hypertension in pregnancy.

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“…Duhig et al [31] demonstrated that using PlGF reduced the time to diagnosis of PE by 2 days with a subsequent lower rate of maternal adverse outcomes. They can also exclude conditions which mimic PE [4 ▪ ,16 ▪▪ ,32], including chronic hypertension [33], chronic kidney disease [32] and non-HELLP thrombocytopaenia [34].…”

Section: Novel Diagnostic Approachesmentioning

confidence: 99%

Novel therapeutic and diagnostic approaches for preeclampsia

Vatish

Powys

Cerdeira

2023

Current Opinion in Nephrology &Amp; Hypertension

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Purpose of reviewThis review will summarize recent findings relating to the diagnostic approach to preeclampsia and current avenues of research aimed at modifying the underlying disease process. Recent findingsGrowing international consensus supports a broad preeclampsia definition that incorporates maternal endorgan and uteroplacental dysfunction. Recent evidence demonstrates that this definition better identifies women and babies at risk of adverse outcomes compared to the traditional definition of hypertension and proteinuria. Multiple studies have demonstrated the usefulness and cost-effectiveness of angiogenic biomarkers such as soluble fms-like tyrosine kinase-1 and placental growth factor as a clinical adjunct to diagnose and predict severity of preeclampsia associated outcomes. Current novel therapeutic approaches to preeclampsia target pathogenic pathways (e.g. antiangiogenesis) or downstream effects such as oxidative stress and nitric oxide. Recent findings relating to these promising candidates are discussed. Multicenter clinical trials are needed to evaluate their effectiveness and ability to improve fetal and maternal outcomes.

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The sFlt-1/PlGF ratio as a triage tool to identify superimposed preeclampsia in women with chronic hypertension in emergency rooms

Cited by 14 publications

References 13 publications

A bibliometric review of 35 years of studies about preeclampsia

A bibliometric review of 35 years of studies about preeclampsia

Should angiogenic markers be included in diagnostic criteria of superimposed pre‐eclampsia in women with chronic hypertension?

Novel therapeutic and diagnostic approaches for preeclampsia

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