The serum insulin-like growth factor-II/mannose-6-phosphate receptor in normal and diabetic pregnancy

Gelato, Marie C.; Rutherford, C; San-Roman, G.; Shmoys, S.; Monheit, Alan G.

doi:10.1016/0026-0495(93)90019-k

Cited by 13 publications

(14 citation statements)

References 22 publications

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“…There was no change in either IGF-I or IGF-II in one study [18]. Our data are consistent with those of Gelato et al [6] who showed 2-fold higher values for IGF-I and 1.3-fold higher values for IGF-II in the cord blood of newborns of diabetic mothers.…”

Section: Relation Between Birth Weight and Serum Concentrations Of Fesupporting

confidence: 92%

“…Earlier studies have shown that the concentrations increase slightly during the latter half of gestation [5][6][7], whereas Funakoshi et al…”

Section: Relation Between Birth Weight and Serum Concentrations Of Fementioning

confidence: 89%

“…Several studies have shown that maternal serum IGF-II levels increased in late pregnancy [5][6][7][8], and in a study by Bennet et al [9], cord IGF-II levels were shown to positively correlate with the birth weight of infants born to normal mothers. Furthermore, Samaan et al [10] reported higher IGF-II in large-for-gestational-age neonates than in average-f or-gestational neonates.…”

Section: Introductionmentioning

confidence: 96%

“…In addition, earlier studies [5,16] have shown that the concentration of IGF-I in cord blood is higher in babies born to diabetic mothers than in newborns of normal mothers, suggesting that IGF-I, as well as insulin, is a factor responsible for the development of macrosomia. It is not clear, however, whether IGF-II is also involved in fetal macrosomia, although Hall et al [17] and Gelato et al [6] have previously shown that the IGF-II concentration in cord blood is higher in babies born to diabetic mothers.…”

Section: Introductionmentioning

confidence: 99%

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Insulin-Like Growth Factors (IGFs) and IGF-Binding Proteins (IGFBP-1, -2 and -3) in Diabetic Pregnancy: Relationship to Macrosomia.

Liu¹,

Tsushima

Minei³

et al. 1996

Endocr J

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Abstract.To evaluate the role of insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) in exessive fetal growth (macrosomia) in diabetic pregnancy, 84 insulin-treated diabetic mothers and their infants were tested for serum concentrations of IGF-I, IFG-II, and IGFBP-1, -2 and -3. These parameters were correlated with the birth weight of neonates and placental weight. IGF-I and II levels were determined by specific radioimmunoassays (RIAs) after serum samples were extracted with aid-ethanol. IGFBPs were measured by Western immunoblot with specific antibodies to the respective IGFBP species.

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Section: Relation Between Birth Weight and Serum Concentrations Of Fesupporting

confidence: 92%

“…Earlier studies have shown that the concentrations increase slightly during the latter half of gestation [5][6][7], whereas Funakoshi et al…”

Section: Relation Between Birth Weight and Serum Concentrations Of Fementioning

confidence: 89%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Insulin-Like Growth Factors (IGFs) and IGF-Binding Proteins (IGFBP-1, -2 and -3) in Diabetic Pregnancy: Relationship to Macrosomia.

Liu¹,

Tsushima

Minei³

et al. 1996

Endocr J

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show abstract

“…In situ hybridization. In situ hybridization was performed in kidney of fetuses on day 16 of gestation as previously described (27,28), using 4% paraformaldehyde-fixed, paraffin-embedded tissues and the 35 S-labeled IGF-II/ M6PR probe. For controls, tissue sections were first treated with ribonuclease A for 30 min and then washed, permeated, and hybridized with the specific probe.…”

mentioning

confidence: 99%

Altered Nephrogenesis Due to Maternal Diabetes Is Associated With Increased Expression of IGF-II/Mannose-6-Phosphate Receptor in the Fetal Kidney

et al. 2001

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We have recently demonstrated that the exposure to hyperglycemia in utero impairs nephrogenesis in rat fetuses (Amri K et al., Diabetes 48:2240 -2245, 1999). Diabetic pregnancy is commonly associated with alterations in the IGF system in fetal tissues. It has also been shown that both IGF-I and IGF-II are produced within developing metanephros and promote renal organogenesis. Therefore, we investigated the effect of maternal diabetes on IGFs and their receptors in developing fetal rat kidney. Diabetes was induced in pregnant rats by a single injection of streptozotocin on day 0 of gestation. We measured the amounts of IGF and their receptors, both proteins and mRNAs, in the metanephroi of fetuses issued from diabetic subjects and in age-matched fetuses from control subjects (14 -20 days of gestation). IGF-II was produced throughout fetal nephrogenesis, whereas IGF-I protein was not detected, suggesting a critical role of IGF-II in kidney development. Fetal exposure to maternal diabetes caused no change in IGF production in the early stages of nephrogenesis. Similarly, the amounts of IGF-I receptor and insulin receptor were not altered. By contrast, there was an increase in production of IGF-II/mannose-6-phosphate receptor throughout nephrogenesis. Because this receptor plays an essential role in regulating the action of IGF-II, the altered nephrogenesis in fetuses exposed to maternal diabetes may be linked to a decrease in IGF-II bioavailability.

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The Placenta in a Diabetic Pregnancy

Hiden

Desoyé

2017

A Practical Manual of Diabetes in Pregnancy

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The serum insulin-like growth factor-II/mannose-6-phosphate receptor in normal and diabetic pregnancy

Cited by 13 publications

References 22 publications

Insulin-Like Growth Factors (IGFs) and IGF-Binding Proteins (IGFBP-1, -2 and -3) in Diabetic Pregnancy: Relationship to Macrosomia.

Insulin-Like Growth Factors (IGFs) and IGF-Binding Proteins (IGFBP-1, -2 and -3) in Diabetic Pregnancy: Relationship to Macrosomia.

Altered Nephrogenesis Due to Maternal Diabetes Is Associated With Increased Expression of IGF-II/Mannose-6-Phosphate Receptor in the Fetal Kidney

The Placenta in a Diabetic Pregnancy

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