The Septin Cytoskeleton is Required for Plasma Membrane Repair
M. Isabella Prislusky,
Jonathan GT Lam,
Viviana Ruiz Contreras
et al.
Abstract:Mammalian cells are frequently exposed to mechanical and biochemical stresses resulting in plasma membrane injuries. Repair mechanisms rapidly reseal the plasma membrane to restore homeostasis and prevent cell death. In the present work, a silencing RNA (siRNA) screen was performed to uncover the plasma membrane repair mechanisms of cells injured by the bacterial pore-forming toxin listeriolysin O (LLO). The screen identified a novel role for the septin cytoskeleton in mediating plasma membrane repair. Upon ce… Show more
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