The sensitive monitoring of living cell-secreted dopamine based on the electrochemical biosensor modified with nitrogen-doped graphene aerogel/Co3O4 nanoparticles

Zou, Xun; Chen, Yuying; Zheng, Zhiyuan; Sun, Mingyan; Song, Xiangfei; Lin, Pei-Ru; Tao, Jia; Zhao, Peng

doi:10.1016/j.microc.2022.107957

Cited by 13 publications

(6 citation statements)

References 60 publications

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“…According to the regression equation, the concentration of dopamine released by cells in cell suspension was 6.574 μM, which is consistent with the previous reports. 37,38 These experimental results demonstrate that CoOOH/ CB/GCE can be used as an effective sensing platform to monitor DA secreted by living cells.…”

Section: Resultsmentioning

confidence: 75%

Dual-Signal Colorimetric and Electrochemical Sensor of Dopamine Based on Nanocomposite of Cobalt Oxyhydroxide/Carbon Black

Zou

Deng

Chen

et al. 2023

J. Electrochem. Soc.

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In this report, a novel electrochemical and colorimetric dual-mode sensing system was developed for the sensitive and selective detection of DA. The large surface area of CoOOH and the excellent conductivity of CB endow the electrochemical sensing system with high sensitivity. CoOOH with oxidase-like activity will convert the colorless TMB into the blue oxidation product OXTMB, appearing an absorption peak at 652 nm correspondingly. And the addition of DA will inhibit the activity of oxidase followed by a reducing in the absorption. The proposed method provided a wider detection range for DA from 1 to 30 μM and 1 to 950 μM through colorimetric and electrochemical methods, respectively. Furthermore, this biosensor with good biocompatibility has been successfully used for tracking of DA efflux from live PC12 cell after being stimulated, which has important scientific and practical value for clinical diagnosis and monitoring.

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Section: Resultsmentioning

confidence: 75%

Dual-Signal Colorimetric and Electrochemical Sensor of Dopamine Based on Nanocomposite of Cobalt Oxyhydroxide/Carbon Black

Zou

Deng

Chen

et al. 2023

J. Electrochem. Soc.

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“…This was made possible by its effective conductivity, high surface area, and catalytic activity. It was demonstrated that the Co-NGA/GCE was capable of realizing the monitoring of DA released by living cells in response to K + stimulation see Figure 4 A [ 108 ]. The Co-NGA/GCE is expected to not only be a perfect tool for DA assay but also to provide a strong alternative to pathogenesis research and medication screening for disorders of the nervous system.…”

Section: Gr-based Ec Sensors For Bioanalytes Detectionmentioning

confidence: 99%

“… ( A ) Drawing of Co-NGA and Co-NGA/GCE used to detect DA secreted by live cells. Reprinted with permission from [ 108 ]. ( B ) Synthesis of Ti 3 C 2 T x -RGO NC and its EC response for ST detection using GCE.…”

Section: Figures Scheme and Tablesmentioning

confidence: 99%

The Roadmap of Graphene-Based Sensors: Electrochemical Methods for Bioanalytical Applications

et al. 2022

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Graphene (GR) has engrossed immense research attention as an emerging carbon material owing to its enthralling electrochemical (EC) and physical properties. Herein, we debate the role of GR-based nanomaterials (NMs) in refining EC sensing performance toward bioanalytes detection. Following the introduction, we briefly discuss the GR fabrication, properties, application as electrode materials, the principle of EC sensing system, and the importance of bioanalytes detection in early disease diagnosis. Along with the brief description of GR-derivatives, simulation, and doping, classification of GR-based EC sensors such as cancer biomarkers, neurotransmitters, DNA sensors, immunosensors, and various other bioanalytes detection is provided. The working mechanism of topical GR-based EC sensors, advantages, and real-time analysis of these along with details of analytical merit of figures for EC sensors are discussed. Last, we have concluded the review by providing some suggestions to overcome the existing downsides of GR-based sensors and future outlook. The advancement of electrochemistry, nanotechnology, and point-of-care (POC) devices could offer the next generation of precise, sensitive, and reliable EC sensors.

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“…Moreover, metal nanoparticles and graphitic materials are potential materials for electrocatalysts because they facilitate charge transfer very quickly while lowering the activation energy of any chemical redox reaction. [39] However, when these materials are used separately or mixed, potential losses occur at the interface of both nanomaterials during the electron transfer process (redox reaction). Thus, the use of copper oxide with carbon nanofibers enhances the charge transfer between support matrices and analytes, further enhancing the electrochemical activity of the sensor.…”

Section: Introductionmentioning

confidence: 99%

Copper Oxide Anchored Carbon Nanofibers: A Versatile Platform for Multiplex Detection of Antibiotics, Heavy Metals and Pesticides

Mishra,

Budania,

Tyagi

et al. 2024

Chemistry An Asian Journal

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Electrochemical sensors offer promising prospects for real‐time pollutant monitoring. In this study, copper oxide‐dispersed graphitic carbon nanofibers (CuO‐CNFs) grown via chemical vapour deposition were employed as a robust platform for detecting a variety of environmental pollutants. This array‐based sensor adeptly identifies three different classes of analytes, i.e., antibiotics (chloramphenicol (CP) and tylosin tartrate (TT)), heavy metals (cadmium (Cd) and lead (Pb)), and pesticides (quinalphos (QP) and imidacloprid (IP)). The CuO‐CNF‐modified GCE array rapidly discerns (<15 sec) a broad linear range: 1‐20 ppm for CP, 1‐13.33 ppm for TT, 0.66‐11.66 ppm for Cd, 20‐33.33 ppm for Pb, 1.6‐11.6 ppm for QP, and 5‐25 ppm for IP, boasting quantification limits of 1.0, 1.0, 0.66, 20.0, 1.6, and 5.0 ppm for CP, TT, Cd, Pb, QP, and IP, respectively. Notably, this sensor achieves simultaneous identification of mixed analytes, including CP and TT, Cd and Pb, and QP and IP, within real tap water. The electrochemical sensor exhibits robustness; heightened sensitivity, selectivity, and stability; swift response; and impressive reproducibility in detecting CP, TT, Cd, Pb, QP, and IP within aqueous samples. Consequently, this array‐based electrochemical sensor has emerged as a rapid and simultaneous detection tool for diverse pollutant residues in surface and groundwater samples.

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The sensitive monitoring of living cell-secreted dopamine based on the electrochemical biosensor modified with nitrogen-doped graphene aerogel/Co3O4 nanoparticles

Cited by 13 publications

References 60 publications

Dual-Signal Colorimetric and Electrochemical Sensor of Dopamine Based on Nanocomposite of Cobalt Oxyhydroxide/Carbon Black

Dual-Signal Colorimetric and Electrochemical Sensor of Dopamine Based on Nanocomposite of Cobalt Oxyhydroxide/Carbon Black

The Roadmap of Graphene-Based Sensors: Electrochemical Methods for Bioanalytical Applications

Copper Oxide Anchored Carbon Nanofibers: A Versatile Platform for Multiplex Detection of Antibiotics, Heavy Metals and Pesticides

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