The selection-induced His+ reversion in Salmonella typhimurium

Gizatullin, Farid; Babynin, E. V.

doi:10.1016/0027-5107(96)00078-4

Cited by 10 publications

(6 citation statements)

References 30 publications

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“…These time periods were short, but correspond to the period of residual DNA synthesis detected after cells were starved for histidine (69) (further discussed below). Although reversion to His + was recA-independent, it was enhanced by SOS mutagenic functions (69).…”

Section: Mutations In the Histidine Operon Of Salmonella Typhimuriummentioning

confidence: 99%

“…When 10 9 cells are plated on minimal glucose plates without histidine, the auxotrophic strains produce 10 to 20 His + colonies over 10 days (125). Most of these appear within 2 days (TA Cebula, personal communication), but a respreading experiment indicated that even the colonies that appear early are due to mutations that occurred during the first 24 h after the cells were plated without histidine (69). Starvation for histidine for 6 h did not induce mutations giving arabinose or rifampicin resistances, nor were His + mutations induced by 6 h starvation for threonine.…”

Section: Mutations In the Histidine Operon Of Salmonella Typhimuriummentioning

confidence: 99%

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Mechanisms of Stationary Phase Mutation: A Decade of Adaptive Mutation

1999

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A decade of research on adaptive mutation has revealed a plethora of mutagenic mechanisms that may be important in evolution. The DNA synthesis associated with recombination could be an important source of spontaneous mutation in cells that are not proliferating. The movement of insertion elements can be responsive to environmental conditions. Insertion elements not only activate and inactivate genes, they also provide sequence homology that allows large-scale genomic rearrangements. Some conjugative plasmids can recombine with their host's chromosome, and may acquire chromosomal genes that could then spread through the population and even to other species. Finally, a subpopulation of transient hypermutators could be a source of multiple variant alleles, providing a mechanism for rapid evolution under adverse conditions.

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Section: Mutations In the Histidine Operon Of Salmonella Typhimuriummentioning

confidence: 99%

Section: Mutations In the Histidine Operon Of Salmonella Typhimuriummentioning

confidence: 99%

Mechanisms of Stationary Phase Mutation: A Decade of Adaptive Mutation

1999

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“…Considerable uptake of Vitiated thymidine was reported by Gizatullin and Babynin during the first 7 hours after plating Salmonella typhimurium on plates lacking histidine, a required amino acid (26). The incorporation was partially blocked by chloramphenicol.…”

Section: Dna Synthesis In Resting Bacteriarecent Studiesmentioning

confidence: 83%

DNA turnover and mutation in resting cells

Bridges

1997

BioEssays

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There is growing evidence that mutations can arise in non-dividing cells (both bacterial and mammalian) in the absence of chromosomal replication. The processes that are involved are still largely unknown but may include two separate mechanisms. In the first, DNA lesions resulting from the action of endogenous mutagens may give rise to RNA transcripts with miscoded bases. If these confer the ability to initiate DNA replication, the DNA lesions may have an opportunity to miscode during replication and thus could give rise to apparently 'adaptive' mutations. A second mechanism is suggested by recent work in starved bacteria, showing that there is much more turnover of chromosomal DNA than has been previously thought. This could permit polymerase errors to lead to mutations in non-dividing cells. Such cryptic DNA synthesis, which may essentially replace existing DNA rather than duplicating it, could, in principle, act as an additional source of variability on which selection may act, initially in the absence of cell division. In mammals such processes would undoubtedly have implications for germ cell mutagenesis and carcinogenesis.

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“…Then the mutation rate is usually defined as mutations per viable cell per day[7,9,10,12,14], marked as μ d in this paper. If the generation time is constant during the selective process, μ d is also proportional to the mutation rate μ and to μ b .…”

Section: Discussionmentioning

confidence: 99%

Untitled

2002

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Background: Many investigations have reported that advantageous mutations occurred more frequently under selective conditions than those under non-selective conditions. This phenomenon is referred to as adaptive mutation. Their characteristics are that adaptive mutations are directed and growth-independent. The idea of directed adaptive mutation had been objected by some reports, however, the idea of growth-independent adaptive mutation has been held till today.

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The selection-induced His+ reversion in Salmonella typhimurium

Cited by 10 publications

References 30 publications

Mechanisms of Stationary Phase Mutation: A Decade of Adaptive Mutation

Mechanisms of Stationary Phase Mutation: A Decade of Adaptive Mutation

DNA turnover and mutation in resting cells

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