The search for chelate antagonists for chronic cadmium intoxication

Antioxidants, cadmium-induced toxicity, serum biochemical and the histological abnormalities of the kidney and testes of the male wistar rats

“…Furthermore, these generalized toxic indices (Friberg 1986) also positively correlated with the damage caused to the testicular tissue. This is also consistent with the earlier works of Jones et al 1988;Massanyi et al 2007 where they showed toxicity but not its correlation. The testes are endocrine organs hence damage to the tissue will result in abnormal endocrine responses.…”

Antioxidants, cadmium-induced toxicity, serum biochemical and the histological abnormalities of the kidney and testes of the male wistar rats

“…Furthermore, these generalized toxic indices (Friberg 1986) also positively correlated with the damage caused to the testicular tissue. This is also consistent with the earlier works of Jones et al 1988;Massanyi et al 2007 where they showed toxicity but not its correlation. The testes are endocrine organs hence damage to the tissue will result in abnormal endocrine responses.…”

Effects of Sulfhydryl Compounds on the Accumulation, Removal and Cytotoxicity of Inorganic Mercury by Primary Cultures of Rat Renal Cortical Epithelial Cells

“…In agreement with this, 2,3-dimercapto-l-propanol removes intracellular Cd bound mainly to metallothionein (Bakka et al 1981). The lipophilic properties of Hg-2,3-dimercapto-1propanol complex and 2,3-dimercapto-1 -propano1 itself (Kiyozumi et al 1988;Jones & Cherian 1990) seem to be due to the lowest decrease ( fig. 1) and the highest removals (table 2), respectively.…”

Mobilisation of Cadmium by meso‐ and racemic‐2,3‐Dimercaptosuccinic Acid (DMSA) in Rats

“…It has been shown earlier that lipophilic compounds such as carbodithioates are the most promising types of chelating agents for cadmium mobilisation following chronic cadmium exposure since they penetrate into the cell and compete with metalothionein for cadmium (Jones & Cherian 1990). This was proved by in vivo experiments of cadmium mobilisation with several bis carbodithioates (Singh et al 1996a).…”

Antioxidants, cadmium-induced toxicity, serum biochemical and the histological abnormalities of the kidney and testes of the male wistar rats

“…Furthermore, these generalized toxic indices (Friberg 1986) also positively correlated with the damage caused to the testicular tissue. This is also consistent with the earlier works of Jones et al 1988;Massanyi et al 2007 where they showed toxicity but not its correlation. The testes are endocrine organs hence damage to the tissue will result in abnormal endocrine responses.…”

Effects of Sulfhydryl Compounds on the Accumulation, Removal and Cytotoxicity of Inorganic Mercury by Primary Cultures of Rat Renal Cortical Epithelial Cells

“…In agreement with this, 2,3-dimercapto-l-propanol removes intracellular Cd bound mainly to metallothionein (Bakka et al 1981). The lipophilic properties of Hg-2,3-dimercapto-1propanol complex and 2,3-dimercapto-1 -propano1 itself (Kiyozumi et al 1988;Jones & Cherian 1990) seem to be due to the lowest decrease ( fig. 1) and the highest removals (table 2), respectively.…”

Mobilisation of Cadmium by meso‐ and racemic‐2,3‐Dimercaptosuccinic Acid (DMSA) in Rats

“…It has been shown earlier that lipophilic compounds such as carbodithioates are the most promising types of chelating agents for cadmium mobilisation following chronic cadmium exposure since they penetrate into the cell and compete with metalothionein for cadmium (Jones & Cherian 1990). This was proved by in vivo experiments of cadmium mobilisation with several bis carbodithioates (Singh et al 1996a).…”

Antioxidants, cadmium-induced toxicity, serum biochemical and the histological abnormalities of the kidney and testes of the male wistar rats

“…Furthermore, these generalized toxic indices (Friberg 1986) also positively correlated with the damage caused to the testicular tissue. This is also consistent with the earlier works of Jones et al 1988;Massanyi et al 2007 where they showed toxicity but not its correlation. The testes are endocrine organs hence damage to the tissue will result in abnormal endocrine responses.…”

Effects of Sulfhydryl Compounds on the Accumulation, Removal and Cytotoxicity of Inorganic Mercury by Primary Cultures of Rat Renal Cortical Epithelial Cells

“…In agreement with this, 2,3-dimercapto-l-propanol removes intracellular Cd bound mainly to metallothionein (Bakka et al 1981). The lipophilic properties of Hg-2,3-dimercapto-1propanol complex and 2,3-dimercapto-1 -propano1 itself (Kiyozumi et al 1988;Jones & Cherian 1990) seem to be due to the lowest decrease ( fig. 1) and the highest removals (table 2), respectively.…”

Mobilisation of Cadmium by meso‐ and racemic‐2,3‐Dimercaptosuccinic Acid (DMSA) in Rats

“…It has been shown earlier that lipophilic compounds such as carbodithioates are the most promising types of chelating agents for cadmium mobilisation following chronic cadmium exposure since they penetrate into the cell and compete with metalothionein for cadmium (Jones & Cherian 1990). This was proved by in vivo experiments of cadmium mobilisation with several bis carbodithioates (Singh et al 1996a).…”