The Safety and Efficacy of a Silymarin and Selenium Combination in Men After Radical Prostatectomy - A Six Month Placebo-Controlled Double-Blind Clinical Trial

Vidlář, Aleš; Vostalová, Jitka; Ulrichová, Jitka; Študent, Vladimír; M, Krajícek; Vrbková, Jana; Šimánek, Vilı́m

doi:10.5507/bp.2010.036

Cited by 39 publications

(36 citation statements)

References 18 publications

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“…Milk thistle extracts and chemical derivatives are used in the treatment of fulminant liver failure caused by death cap mushroom (Amanita phalloides) poisoning (Mengs et al, 2012). Although milk thistle research remains focused on liver ailments, recent research has highlighted potential uses for treatment of obsessive compulsive disorder (Sayyah et al, 2010;Camfield et al, 2011), type II diabetes (Huseini et al, 2006), b-thalassemia major (Gharagozloo et al, 2009), influenza A (Song and Choi, 2011), and prostate cancer chemoprevention (Agarwal et al, 2006;Flaig et al, 2007;Vidlar et al, 2010). Continuous use of milk thistle products for nearly 2000 years in treating various ailments suggests putative efficacy, but again, clinical evidence remains limited.…”

Section: Case Study: Milk Thistlementioning

confidence: 99%

Herb–Drug Interactions: Challenges and Opportunities for Improved Predictions

et al. 2013

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Supported by a usage history that predates written records and the perception that "natural" ensures safety, herbal products have increasingly been incorporated into Western health care. Consumers often self-administer these products concomitantly with conventional medications without informing their health care provider(s). Such herb-drug combinations can produce untoward effects when the herbal product perturbs the activity of drug metabolizing enzymes and/or transporters. Despite increasing recognition of these types of herb-drug interactions, a standard system for interaction prediction and evaluation is nonexistent. Consequently, the mechanisms underlying herb-drug interactions remain an understudied area of pharmacotherapy. Evaluation of herbal product interaction liability is challenging due to variability in herbal product composition, uncertainty of the causative constituents, and often scant knowledge of causative constituent pharmacokinetics. These limitations are confounded further by the varying perspectives concerning herbal product regulation. Systematic evaluation of herbal product drug interaction liability, as is routine for new drugs under development, necessitates identifying individual constituents from herbal products and characterizing the interaction potential of such constituents. Integration of this information into in silico models that estimate the pharmacokinetics of individual constituents should facilitate prospective identification of herb-drug interactions. These concepts are highlighted with the exemplar herbal products milk thistle and resveratrol. Implementation of this methodology should help provide definitive information to both consumers and clinicians about the risk of adding herbal products to conventional pharmacotherapeutic regimens.

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Section: Case Study: Milk Thistlementioning

confidence: 99%

Herb–Drug Interactions: Challenges and Opportunities for Improved Predictions

et al. 2013

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“…Details of the 18 excluded studies are given in Table 2 [4,[25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41].…”

Section: Description Of Studiesmentioning

confidence: 99%

Phytotherapeutic interventions in the management of biochemically recurrent prostate cancer: a systematic review of randomised trials

et al. 2016

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ObjectiveTo evaluate the evidence from randomised trials for the efficacy and safety of phytotherapeutic interventions in the management of biochemically recurrent (BCR) prostate cancer, indicated by prostate-specific antigen (PSA) progression, numbers progressing to/time to initiation of androgen-deprivation therapy or salvage therapy. Patients and MethodsMEDLINE (Ovid), EMBASE (Ovid), AMED (Ovid), CINAHL (EBSCO) and the Cochrane Library databases were searched. Clinical trials investigating phytotherapeutic interventions as dietary supplements or dietary components, including multicomponent herbal formulations, in men with BCR prostate cancer were located. Eight of nine authors contacted for further information responded. Methodological quality was assessed using the Cochrane Collaboration's risk of bias assessment tool. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement for reporting systematic reviews was followed. ResultsOf 23 full-text articles assessed for eligibility, five met the criteria for inclusion. Two studies were placebo controlled; two were active control trials; and one a high-/low-dose trial. The interventions were administered as isolated phytochemicals (sulphoraphane), phytotherapeutic extracts [Pomi-T (pomegranate, turmeric, green tea and broccoli sprout extract), soy, lycopene, and POMx (pomegranate extract)], or plant-derived dietary items (soy and lycopene). All studies found serum PSA levels to stabilise, decrease or rise more slowly in a significant number of men, and three studies reported stabilising or lengthening of PSA-doubling time. Studies were generally of good quality, but sample sizes were predominantly small, and durations short. ConclusionsHigh-quality studies in this area are lacking. Sulphoraphane, lycopene, soy isoflavones, POMx, and Pomi-T are safe and well tolerated. There is limited evidence that they can affect PSA dynamics. No recommendation can be made for the use of these agents in managing prostate cancer morbidity and mortality until high-quality, fully powered studies are available. Recommendations are made for improving reproducibility and translation of findings with regard to study population, study endpoints, design, and the reporting of phytotherapeutic interventions.

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“…When cooked these leaves make a great spinach substitute. Flower buds can be cooked [21][22][23][24][25][26]. The stems can be eaten raw or cooked for its sweat favorite.…”

Section: Introductionmentioning

confidence: 99%

Wild Milk Thistle Unique Fatty Plant

2017

IJSR

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Milk thistle Silybum Marianum L. annual or biennial wild winter plant belongs to Asteraceae family widespread in north of Iraq particularly in Sulaimaniyah province. The botanical survey revealed that this plant became a third in coverage degree. Plant density reached 4.8plant / m 2 , replication 40 %, found the higher plant in height was 110 cm. This region is rich in floras vegetation cover which could be invested for anti-desertification, soil protection, sustainable biodiversity development and improvement of natural pastures. Its importance appearance as a medically by treating some diseases, milk thistle is better known as having medicinal benefits. It is a great tonic, increases appetite and aids in digestion. Including those who were addicted to alcohol to cleanse the liver. Used internally in the treatment of liver and gall bladder diseases, jaundice, cirrhosis, hepatitis and poisoning (including mushroom poisoning) through its containing several medicinal components as; linoleic acid64.59%, oleic acid23.59%, palmitic acid 12.62%and stearic acid 5.9%. Treating components; silymarin 1.5-3% tocopherol and 0.63% sterols. Including Cholesterol, camp sterol, stigma sterol, sit sterol and some mucilage, the three principle components of silymarin are the flavanoligans silybin, silychristin, and silidianin. To plant nutritional importance due to its seeds components for the follows; protein23%, oils 26.65 %, ash 3.4%, fiber4.55% and carbohydrates 37.72%. Also the plant contain some important elements such as magnesium, calicium; zinc and iron…etc.. Plant leaves as food eaten peaks cutworms and fresh as it palatable and useful of nutritional value. Contains mucilage substances, vitamins (A, B12, C, E, K) andsugars.

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The Safety and Efficacy of a Silymarin and Selenium Combination in Men After Radical Prostatectomy - A Six Month Placebo-Controlled Double-Blind Clinical Trial

Cited by 39 publications

References 18 publications

Herb–Drug Interactions: Challenges and Opportunities for Improved Predictions

Herb–Drug Interactions: Challenges and Opportunities for Improved Predictions

Phytotherapeutic interventions in the management of biochemically recurrent prostate cancer: a systematic review of randomised trials

Wild Milk Thistle Unique Fatty Plant

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