The S2 subunit of spike encodes diverse targets for functional antibody responses to SARS-CoV-2
Jamie Guenthoer,
Meghan E Garrett,
Michelle Lilly
et al.
Abstract:The SARS-CoV-2 virus responsible for the COVID-19 global pandemic has exhibited a striking capacity for viral evolution that drives continued evasion from vaccine and infection-induced immune responses. Mutations in the receptor binding domain of the S1 subunit of the spike glycoprotein have led to considerable escape from antibody responses, reducing the efficacy of vaccines and monoclonal antibody (mAb) therapies. Therefore, there is a need to interrogate more constrained regions of Spike, such as the S2 sub… Show more
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