The rs6505162 C>A polymorphism in themiRNA-423gene exhibits a protective element of coronary artery in a southern Chinese population with Kawasaki disease

Abstract

BackgroundManifesting as acute rash, fever and vasculitis, belonging to autoimmune syndrome, Kawasaki disease(KD) is prone to occur in infants and young children. Males and females is affected by KD at a ratio of 1.4 to 1.7: 1. KD is known to own many common clinical manifestations and complications, like coronary artery lesion(CAL) and coronary artery aneurysm(CAA). Polymorphisms of the rs6505162 locus in themiRNA-423gene are associated with enhancive susceptibility to coronary artery disease and the alterations of the four cytokines IL-4., IL-10, IL-21, IL-22 in the early stages of diabetes. However, no researcher has reported whether rs6505162 is related to KD susceptibility or no. Therefore, we carried out the trial concentrating on the connection betweenmiRNA-423rs6505162 C>A polymorphism and KD susceptibility.MethodsTo obtain the genotypes of rs6505162inobjects enrolled by 532 KD children and 623 control, we applied Taqman real-time PCR and all statistical analyses was carried out by SAS.ResultsThe comparison between all cases and all controls hinted that the rs6505162C>A polymorphism has no relationship with KD susceptibility. Nevertheless, a subgroup analysis revealed that the CA/AA genotypes of rs6505162 could reduce the occurrence of CAA (Adjusted age and gender odds ratio=1.30, 95%CI=1.02-1.67,P=0.037) and CAL (Adjusted OR=1.56, 95%CI=1.19-2.03,P=0.001)in KD patients.ConclusionOur final results stated clearly thatmiRNA-423rs6505162 polymorphism appears to be a protective element of CAL and CAA in southern Chinese suffers with KD.

Deciphering the Variants Located in the MIR196A2, MIR146A, and MIR423 with Type-2 Diabetes Mellitus in Pakistani Population

“…Other studies have identified the association of rs6505162 C/A with the risk of Esophageal Squamous Cell Carcinoma [58]. Although rs6505162 C/A is not situated in the seed region of the mature miRNAs, it has been proposed that rs6505162 C/A can alter not only the mature miR-423 expression [59] ( Zhao et al, 2015), but it may also modulate its targeting efficiency [19]. Other studies have shown that the CA/AA genotypes of rs6505162 C/A could reduce the occurrence of artery aneurysms [59].…”

“…Although rs6505162 C/A is not situated in the seed region of the mature miRNAs, it has been proposed that rs6505162 C/A can alter not only the mature miR-423 expression [59] ( Zhao et al, 2015), but it may also modulate its targeting efficiency [19]. Other studies have shown that the CA/AA genotypes of rs6505162 C/A could reduce the occurrence of artery aneurysms [59]. The rs6505162 C/A is reported to have a role in different diseases including Type 2 Diabetes.…”