volume 5, issue 10, Pe13363 2010
DOI: 10.1371/journal.pone.0013363
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Abstract: BackgroundMicroseminoprotein-beta (MSMB) regulates apoptosis and using genome-wide association studies the rs10993994 single nucleotide polymorphism in the MSMB promoter has been linked to an increased risk of developing prostate cancer. The promoter location of the risk allele, and its ability to reduce promoter activity, suggested that the rs10993994 risk allele could result in lowered MSMB in benign tissue leading to increased prostate cancer risk.Methodology/Principal FindingsMSMB expression in benign and …

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