2011
DOI: 10.1016/j.mrrev.2011.07.001
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Abstract: The accumulation of DNA damage is a slow but hazardous phenomenon that may lead to cell death, accelerated aging features and cancer. One of the most versatile and important defense mechanisms against the accumulation of DNA damage is Nucleotide Excision Repair (NER), in which the Xeroderma pigmentosum group C (XPC) protein plays a prominent role. NER can be divided into Global Genome repair (GG-NER) and Transcription Coupled repair (TC-NER). XPC is a key factor in GG-NER where it functions in DNA damage recog… Show more

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Cited by 53 publications
(44 citation statements)
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References 131 publications
(151 reference statements)
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“…Because it searches lesions anywhere in the genome, GG-NER is considered to be a slow, transcriptionindependent process, less efficient than TC-NER. Nevertheless, 6-4PPs, which trigger helix distortions, are rapidly suppressed by GG-NER, while CPD removal is achieved efficiently by TC-NER on the transcribed strand (254).…”
Section: Fig 10mentioning
confidence: 99%
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“…Because it searches lesions anywhere in the genome, GG-NER is considered to be a slow, transcriptionindependent process, less efficient than TC-NER. Nevertheless, 6-4PPs, which trigger helix distortions, are rapidly suppressed by GG-NER, while CPD removal is achieved efficiently by TC-NER on the transcribed strand (254).…”
Section: Fig 10mentioning
confidence: 99%
“…To displace RNA PolIII, CSB interacts directly with it, while CSA is known to interact with CSB, XPA-binding protein 2 (XAB2), and the p44 subunit of the TFIIH complex. Here, CSA and CSB recruitment plays a crucial role in TC-NER, where cells from patients with Cockayne's syndrome exhibit normal GG-NER, deficient TC-NER, and UV light sensitivity (254,262). In trypanosomatids, XPC, Rad23, and DDB1 (XPE) proteins involved in recognition of global genome repair have been identified, while only CSB (Rad26) is present for TC-NER (22) (see Fig.…”
Section: Fig 10mentioning
confidence: 99%
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“…How does XPC deficiency affect ROS-mediated DNA repair? In the last few years, increasing evidence indicate that XPC may be involved in repairing of oxidative DNA damages, either through NER or BER (Melis et al, 2011). NER is known to recognize and repair bulky DNA adducts and helix-distorting structures.…”
Section: Discussionmentioning
confidence: 99%
“…The XPC complex is the initiator and main DNA damage sensor in global genome nucleotide excision repair (GG-NER), one of two branches of the nucleotide excision repair pathway that repairs a wide array of bulky, helixdistorting lesions (2,11); the second form of NER or transcription-coupled repair (TC-NER) targets lesions blocking transcription to reactivate proper gene expression (2,12). Defects in GG-NER lead to photosensitivity and a predisposition to certain cancers in animal models and in human patients with Xeroderma pigmentosum (13). In conjunction with the UV-damage DNA-binding protein (UV-DDB) (2,12), the XPC complex recruits >30 downstream factors, such as XPA (14), TFIIH (15,16), and the endonucleases XPF and XPG to remove these adducts (2, 11).…”
mentioning
confidence: 99%