The Role of Vitamin D in the Management of Chronic Pain in Fibromyalgia: A Narrative Review

Haddad, Hannah; Jumonville, Allison; Stark, Katarina; Temple, Shavonne N.; Dike, Chukwudum C.; Cornett, Elyse M.; Kaye, Alan D.

doi:10.52965/001c.25208

Cited by 5 publications

(5 citation statements)

References 81 publications

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“…To date, extremely discordant data exist regarding the potential role of hypovitaminosis D in FM patients and, even if a higher prevalence of hypovitaminosis D cannot be excluded in these patients, questions remain regarding the effective pathophysiological role of vitamin D. Possible alternative explanations are that hypovitaminosis D could be a consequence of limited exercise and sun exposure, both favored by chronic pain [ 205 ], or it could simply reflect a characteristic of the general local population considered [ 203 ]. Future research is warranted, focusing on prospective study designs that exhaustively account for confounders and potentially problematic methodological pitfalls, in order to ascertain any causative role of vitamin D in the development of FM [ 199 ].…”

Section: Potential Future Directionsmentioning

confidence: 99%

“…Safe clinical conclusions are hindered by several limitations of the studies conducted, such as the absence of a control group, small sample size and discrepancies in the type, regimen and dose of vitamin D supplements administered [ 197 ]. Nonetheless, authors agree that FM patients should be screened for hypovitaminosis D and, if it is present, supplementation should be administered not only to maintain bone health [ 204 ] but also for the possible positive impact on pain perception and quality of life [ 205 ].…”

Section: Potential Future Directionsmentioning

confidence: 99%

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Pain Biomarkers in Fibromyalgia Syndrome: Current Understanding and Future Directions

Favretti

Iannuccelli

Franco

2023

IJMS

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Fibromyalgia is a complex and heterogeneous clinical syndrome, mainly characterized by the presence of widespread pain, possibly associated with a variety of other symptoms. Fibromyalgia can have an extremely negative impact on the psychological, physical and social lives of people affected, sometimes causing patients to experience dramatically impaired quality of life. Nowadays, the diagnosis of fibromyalgia is still clinical, thus favoring diagnostic uncertainties and making its clear identification challenging to establish, especially in primary care centers. These difficulties lead patients to undergo innumerable clinical visits, investigations and specialist consultations, thus increasing their stress, frustration and even dissatisfaction. Unfortunately, research over the last 25 years regarding a specific biomarker for the diagnosis of fibromyalgia has been fruitless. The discovery of a reliable biomarker for fibromyalgia syndrome would be a critical step towards the early identification of this condition, not only reducing patient healthcare utilization and diagnostic test execution but also providing early intervention with guideline-based treatments. This narrative article reviews different metabolite alterations proposed as possible biomarkers for fibromyalgia, focusing on their associations with clinical evidence of pain, and highlights some new, promising areas of research in this context. Nevertheless, none of the analyzed metabolites emerge as sufficiently reliable to be validated as a diagnostic biomarker. Given the complexity of this syndrome, in the future, a panel of biomarkers, including subtype-specific biomarkers, could be considered as an interesting alternative research area.

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Section: Potential Future Directionsmentioning

confidence: 99%

Section: Potential Future Directionsmentioning

confidence: 99%

Pain Biomarkers in Fibromyalgia Syndrome: Current Understanding and Future Directions

Favretti

Iannuccelli

Franco

2023

IJMS

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“…For instance, high levels of serum glutamate and aspartate were reported in patients with chronic migraine, orofacial pain, fibromyalgia, and complex regional pain syndrome [ 75 , 76 , 77 , 78 ]. Low levels of nutrients are also commonly recognized, such as vitamin D, omega-3 polyunsaturated fatty acid, vitamin B12, magnesium, zinc, ferritin, selenium, and folic acid [ 56 , 79 ]. Although, these studies do not draw conclusive and direct links with the aetiology of chronic pain, it is anticipated that chronic pain patients may have altered eating behaviors, either before the onset of pain or during the development of pain.…”

Section: The Nutrition-related Health Of People Experiencing Painmentioning

confidence: 99%

“…As outlined in Section 3.2 , there are several micronutrient deficiencies that are commonly associated with chronic pain, such as the B-group vitamins and Vitamin D [ 56 , 79 , 82 , 157 ]. These can be identified through routine pathology tests.…”

Section: Implementation and Scope Of Nutrition In Chronic Pain Manage...mentioning

confidence: 99%

The Importance of Nutrition as a Lifestyle Factor in Chronic Pain Management: A Narrative Review

Elma

Brain

Dong

2022

JCM

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In everyday clinical practice, healthcare professionals often meet chronic pain patients with a poor nutritional status. A poor nutritional status such as malnutrition, unhealthy dietary behaviors, and a suboptimal dietary intake can play a significant role in the occurrence, development, and prognosis of chronic pain. The relationship between nutrition and chronic pain is complex and may involve many underlying mechanisms such as oxidative stress, inflammation, and glucose metabolism. As such, pain management requires a comprehensive and interdisciplinary approach that includes nutrition. Nutrition is the top modifiable lifestyle factor for chronic non-communicable diseases including chronic pain. Optimizing one’s dietary intake and behavior needs to be considered in pain management. Thus, this narrative review reports and summarizes the existing evidence regarding (1) the nutrition-related health of people experiencing pain (2) the underlying potential mechanisms that explain the interaction between nutrition and chronic pain, and (3) the role of nutrition screening, assessment and evaluation for people experiencing pain and the scope of nutrition practice in pain management. Future directions in the nutrition and chronic pain field are also discussed.

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“…Physical and emotional stress, as well as cold weather, can provoke symptoms [4]. The treatment of fibromyalgia involves a multidisciplinary approach, including lifestyle modifications, medical treatment, nutritional support, and cognitive-behavioral therapies [5]. Serotonin-norepinephrine reuptake inhibitors (SNRIs) and antiepileptic drugs are commonly preferred medical agents for pharmacological treatment due to their side effect profile [6].…”

Section: Introductıonmentioning

confidence: 99%

The effect of vitamin D treatment on quality of life in patients with fibromyalgia

Ersoy,

Kesiktas,

Sirin

et al. 2023

Ir J Med Sci

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Background Fibromyalgia is a syndrome characterized by chronic widespread pain accompanied by fatigue, disrupted sleep quality, cognitive impairments, subjective soft tissue swelling, and somatic symptoms. There are conflicting results in the literature regarding the prevalence of vitamin D deficiency in fibromyalgia patients and the reduction of symptoms after supplementation. Aims Our study aims to evaluate the effectiveness and reliability of vitamin D supplementation in patients diagnosed with fibromyalgia. Methods In our cross-sectional clinical study, 180 female patients aged 18 to 65 diagnosed with fibromyalgia according to the 2010 American College of Rheumatology Diagnostic Criteria were included. Oral vitamin D3 replacement of 50,000 IU was administered for 12 weeks. Patients' Fibromyalgia Impact Questionnaire (FIQ)and Visual Analogue Scale (VAS) scores were evaluated before and after the study. Results Significant differences were observed in the FIQ scores of the 180 fibromyalgia patients before and after vitamin D supplementation (p < 0.05). There was also a significant improvement in VAS scores (p < 0.01). A negative correlation between vitamin D and VAS as well as FIQ scores was found in the study. Conclusion We determined that vitamin D deficiency is significantly more prevalent in patients diagnosed with fibromyalgia. Vitamin D supplementation was observed to have a positive effect on quality of life and reduction of pain.

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The Role of Vitamin D in the Management of Chronic Pain in Fibromyalgia: A Narrative Review

Cited by 5 publications

References 81 publications

Pain Biomarkers in Fibromyalgia Syndrome: Current Understanding and Future Directions

Pain Biomarkers in Fibromyalgia Syndrome: Current Understanding and Future Directions

The Importance of Nutrition as a Lifestyle Factor in Chronic Pain Management: A Narrative Review

The effect of vitamin D treatment on quality of life in patients with fibromyalgia

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