The role of vesicular overexpressed in cancer pro-survival protein 1 in hepatocellular carcinoma proliferation

Fang, Zheping; Wu, Lixin; Dai, Hanyi; Hu, Peng; Wang, Binfeng; Han, Qiu‐Yue; Xu, Yanping; Lv, Shangdong; Zhu, Yu; Gan, Meifu; Zhou, Weijie; Zhang, Wenlong

doi:10.3233/cbm-190574

Cited by 6 publications

(6 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…12 VOPP1 promotes cell proliferation and migration, and inhibits apoptosis. 13,15 However, its expression and function in HCC are poorly understood.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: RNA polymerase II subunit 3 regulates vesicular, overexpressed in cancer, prosurvival protein 1 expression to promote hepatocellular carcinoma

Wang

Chen

et al. 2021

J Int Med Res

Self Cite

View full text Add to dashboard Cite

Objective To explore the relationships between hepatocellular carcinoma (HCC) and the expression of RNA polymerase II subunit 3 (RPB3) and vesicular, overexpressed in cancer, prosurvival protein 1 (VOPP1), and to determine whether RPB3 regulates VOPP1 expression to promote HCC cell proliferation, tumor growth, and tumorigenesis. Methods HCC and adjacent liver samples were collected from 51 patients with HCC who underwent surgical excision between September 20, 2010 and June 22, 2017. Immunohistochemical staining, western blot, quantitative PCR, plate colony assay, and RNA microarray were used to detect relevant indexes for further analyses. Results VOPP1 was shown to function as a target gene of RPB3 in facilitating HCC proliferation, and was downregulated after RBP3 silencing. Additionally, hepatic tumor tissues demonstrated high VOPP1 expression. Furthermore, VOPP1 silencing suppressed tumor growth and cell proliferation and elicited apoptosis. Conclusion RPB3 regulates VOPP1 expression to promote HCC cell proliferation, tumor growth, and tumorigenesis.

show abstract

“…12 VOPP1 promotes cell proliferation and migration, and inhibits apoptosis. 13,15 However, its expression and function in HCC are poorly understood.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: RNA polymerase II subunit 3 regulates vesicular, overexpressed in cancer, prosurvival protein 1 expression to promote hepatocellular carcinoma

Wang

Chen

et al. 2021

J Int Med Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…Kartik et al also demonstrated that EGFR-RAD51 fusions are oncogenic in preclinical studies and is able to activate downstream tumorigenic signaling via the MAPK and PI3K/AKT pathways (1). As an anti-apoptotic protein, VOPP1 overexpression has been observed in multiple malignancies such as hepatocellular carcinoma, glioblastoma and breast cancers (18)(19)(20). VOPP1 was one of the most recurrent partners involved in potential oncogenic fusions in glioblastoma (20).…”

Section: Discussionmentioning

confidence: 99%

Emerging a Novel VOPP1-EGFR Fusion Coexistent With T790M as an Acquired Resistance Mechanism to Prior Icotinib and Sensitive to Osimertinib in a Patient With EGFR L858R Lung Adenocarcinoma: A Case Report

et al. 2021

View full text Add to dashboard Cite

BackgroundEpidermal growth factor receptor (EGFR) fusions are rare genomic events in non-small-cell lung cancer (NSCLC). Clinical support and evidence to guide management are absent for NSCLC patients harboring EGFR fusion.Case PresentationIn this case report, we describe a 69-year-old female who received right lobectomy and was diagnosed with pathological stage IIIA lung adenocarcinoma harboring EGFR L858R. Twenty months later he had recurrent disease in the liver, lung, and bone, and was treated with icotinib. A novel vesicular overexpressed in cancer pro-survival protein 1 (VOPP1)-EGFR fusion gene coexistent with T790M were identified by next-generation sequencing using pericardial effusion and blood samples after icotinib treatment, which led to progression after icotinib six months and suggested a potential resistance mechanism. Subsequently, the patient was switched to osimertinib treatment, which resulted in a progression-free survival interval of more than 11 months.ConclusionsThe present results suggested that acquired VOPP1-EGFR fusion gene with T790M potentially serve an additional resistance mechanism to first-generation EGFR tyrosine kinase inhibitors in EGFR-mutated NSCLC. And the present case increases the evidence supporting use of osimertinib for treatment of NSCLC patients harboring EGFR fusion.

show abstract

“…VOPP1 expression has been reported to be upregulated in various types of cancer, including colorectal cancer, squamous cell carcinoma, gastric cancer and glioblastoma ( 29 ). VOPP1 has been demonstrated to promote cell proliferation and migration, and inhibit apoptosis in SMMC-7721 and BEL-7404 cells ( 30 ) and human squamous cell carcinoma cell lines ( 31 ), and suppression of VOPP1 expression attenuates EMT and the subsequent intrusion and metastasis of human lung adenocarcinoma cells ( 13 ). VOPP1 acts as an essential gene for RPB3 for hepatocellular carcinoma proliferation ( 30 ).…”

Section: Discussionmentioning

confidence: 99%

“…VOPP1 has been demonstrated to promote cell proliferation and migration, and inhibit apoptosis in SMMC-7721 and BEL-7404 cells ( 30 ) and human squamous cell carcinoma cell lines ( 31 ), and suppression of VOPP1 expression attenuates EMT and the subsequent intrusion and metastasis of human lung adenocarcinoma cells ( 13 ). VOPP1 acts as an essential gene for RPB3 for hepatocellular carcinoma proliferation ( 30 ). However, in breast cancer cells, VOPP1 may promote cellular transformation and enhance the growth of transplanted tumors by inhibiting the antitumor effect of WW domain-containing oxidoreductase ( 32 ).…”

Section: Discussionmentioning

confidence: 99%

Long non‑coding RNA OIP5‑AS1 promotes the progression of esophageal cancer by regulating miR‑30a/VOPP1 expression

Chen

Fang

et al. 2021

Oncol Lett

View full text Add to dashboard Cite

Long non-coding RNAs (lncRNAs) serve an important role in the development of esophageal cancer (EC), which is the eighth most common type of cancer worldwide. lncRNA opa-interacting protein 5 antisense transcript 1 (OIP5-AS1) is associated with human malignancy. However, the biological roles of OIP5-AS1 in the development of EC remain unclear. In the present study, transfection was conducted, and reverse transcription-quantitative PCR and western blot analysis were used for the detection of mRNA and protein expression, respectively. Furthermore, dual-luciferase reporter and RNA immunoprecipitation assays were used to study the interaction between miRNA and lncRNA or genes. The results revealed that OIP5-AS1 expression in EC tissues and cultured EC cells was upregulated, microRNA-30a (miR-30a) expression was downregulated. OIP5-AS1-knockdown suppressed the proliferation, migration and invasion of EC9706 and EC109 cells. miR-30a was confirmed to interact with OIP5-AS1, and miR-30a-mimics transfection ameliorated the effects of OIP5-AS1 in EC cells. Vesicular overexpressed in cancer prosurvival protein 1 (VOPP1) was verified as the direct target of miR-30a. VOPP1 expression was positively correlated with OIP5-AS1 expression in EC cells. Overexpression of VOPP1 ameliorated the negative effects of OIP5-AS1-knockdown on EC9706 and EC109 cells. In conclusion, OIP5-AS1 promoted the proliferation, migration and invasion of EC cells by increasing VOPP1 expression by sponging miR-30a.

show abstract

The role of vesicular overexpressed in cancer pro-survival protein 1 in hepatocellular carcinoma proliferation

Cited by 6 publications

References 29 publications

RETRACTED: RNA polymerase II subunit 3 regulates vesicular, overexpressed in cancer, prosurvival protein 1 expression to promote hepatocellular carcinoma

RETRACTED: RNA polymerase II subunit 3 regulates vesicular, overexpressed in cancer, prosurvival protein 1 expression to promote hepatocellular carcinoma

Emerging a Novel VOPP1-EGFR Fusion Coexistent With T790M as an Acquired Resistance Mechanism to Prior Icotinib and Sensitive to Osimertinib in a Patient With EGFR L858R Lung Adenocarcinoma: A Case Report

Long non‑coding RNA OIP5‑AS1 promotes the progression of esophageal cancer by regulating miR‑30a/VOPP1 expression

Contact Info

Product

Resources

About