The Role of Tumor Epithelial-Mesenchymal Transition and Macrophage Crosstalk in Cancer Progression

May, Allison M; Batoon, Lena; McCauley, Laurie K.; Keller, Evan T.

doi:10.1007/s11914-023-00780-z

Cited by 3 publications

(2 citation statements)

References 121 publications

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“…CellphoneDB indicated that FGFR, as an EMT receptor, may have indispensable effects on functional maintenance of such tumor cells, with which the corresponding ligand cells, especially macrophages and mesenchymal stromal cells, manifested the most abundant crosstalks, elucidating the close association of the two immune cell subtypes with the EMT of cancer cells. These findings are in tandem with those of previous studies [ 50 – 52 ], which reported on the functions of FGFR in mediating EMT and angiogenesis of cancers [ 31 ], thereby highlighting the great potential of targeting FGFR, especially the FGFR2 receptor, in reversing the EMT process of ccRCC. The LGALS9-related ligands and receptors are of significance in functionally heterogeneous cancer cells of the inflammatory program, which is involved in cancer cell immune escape.…”

Section: Discussionsupporting

confidence: 88%

Unfolding the mysteries of heterogeneity from a high-resolution perspective: integration analysis of single-cell multi-omics and spatial omics revealed functionally heterogeneous cancer cells in ccRCC

Zheng,

Lu,

Wang

et al. 2024

Aging

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The genomic landscape of clear cell renal cell carcinoma (ccRCC) has a considerable intra-tumor heterogeneity, which is a significant obstacle in the field of precision oncology and plays a pivotal role in metastasis, recurrence, and therapeutic resistance of cancer. The mechanisms of intra-tumor heterogeneity in ccRCC have yet to be fully established. We integrated single-cell RNA sequencing (scRNA-seq) and transposase-accessible chromatin sequencing (scATAC-seq) data from a single-cell multi-omics perspective. Based on consensus non-negative matrix factorization (cNMF) algorithm, functionally heterogeneous cancer cells were classified into metabolism, inflammatory, and EMT meta programs, with spatial transcriptomics sequencing (stRNA-seq) providing spatial information of such disparate meta programs of cancer cells. The bulk RNA sequencing (RNA-seq) data revealed high clinical prognostic values of functionally heterogeneous cancer cells of three meta programs, with transcription factor regulatory network and motif activities revealing the key transcription factors that regulate functionally heterogeneous ccRCC cells. The interactions between varying meta programs and other cell subpopulations in the microenvironment were investigated. Finally, we assessed the sensitivity of cancer cells of disparate meta programs to different anti-cancer agents. Our findings inform on the intra-tumor heterogeneity of ccRCC and its regulatory networks and offers new perspectives to facilitate the designs of rational therapeutic strategies.

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Section: Discussionsupporting

confidence: 88%

Unfolding the mysteries of heterogeneity from a high-resolution perspective: integration analysis of single-cell multi-omics and spatial omics revealed functionally heterogeneous cancer cells in ccRCC

Zheng,

Lu,

Wang

et al. 2024

Aging

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“… 21 In a previous study, the pooled 5‐year overall survival rate of patients with pulmonary metastases after resection in liver cancer was about 33%. 33 Epithelial‐to‐mesenchymal transformation (EMT) is an important and complicated mechanism, through which cancer cells acquire stemness, detach from the primary site, displace to distant organs, 34 and develop chemoresistance, 35 , 36 , 37 leading to poor prognosis. EMT also applies to GTN patients, especially for invasion and metastasis.…”

Section: Discussionmentioning

confidence: 99%

Effect of lung metastasis on the treatment and prognosis of patients with gestational trophoblastic neoplasia: A systematic review and meta‐analysis

Zhang,

Guo,

et al. 2024

Acta Obstet Gynecol Scand

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IntroductionGestational trophoblastic neoplasia (GTN) is a highly invasive tumor, mainly spreading to the lungs. However, lung metastasis in GTN is usually not considered as an adverse prognostic factor. Therefore, the aim of this study was to summarize the results of previous studies and evaluate the effects of lung metastasis on the treatment and prognosis of GTN.Material and methodsThe study was prospectively registered in PROSPERO (CRD42023372371). Electronic databases including PubMed, Embase, the Cochrane Library, Chinese National Knowledge Infrastructure, Wanfang, and China Biomedical Literature Database were used for a systematical search of relevant studies published up to November 21, 2022. The observational studies reporting the clinical outcomes of GTN patients with and without lung metastasis were selected. The incidences of resistance, relapse, and mortality of GTN patients were extracted and successively grouped based on the presence of lung metastasis. The pooled relative risks (RRs) and 95% confidence interval (95% CI) of the eligible studies were calculated. The qualities of included studies were assessed with the Newcastle‐Ottawa Scale and the certainty of evidence was graded based on the GRADE. The meta‐analysis was performed using Stata 12.0 and GradePro software.ResultsFive publications with 3629 GTN patients were included. The meta‐analysis revealed that the GTN with lung metastasis was strongly correlated with first‐line chemoresistance (pooled RR = 1.40, 95% CI: 1.22 to 1.61, p < 0.001), recurrence (pooled RR = 3.03, 95% CI: 1.21 to 7.62, p = 0.018), and disease‐specific death (pooled RR = 22.11, 95% CI: 3.37 to 145.08, p = 0.001). Ethnicity was also an important factor and Caucasian GTN patients with lung metastasis showed a higher risk of recurrence as revealed by the subgroup analysis (pooled RR = 5.10, 95% CI: 2.38 to 10.94, p < 0.001).ConclusionsGTN patients with lung metastasis exhibited a higher risk of chemoresistance, relapse, and disease‐specific death. Patients with lung metastasis among the Caucasian population had a higher risk of recurrence than Asian populations. Therefore, the presence of lung metastases might be considered as a high‐risk factor for prognosis of GTN and deserves more attention in the choice of first‐line chemotherapy regimens and follow‐up.

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Exosomes on the development and progression of renal fibrosis

Wang,

Chen,

et al. 2024

Cell Proliferation

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Renal fibrosis is a prevalent pathological alteration that occurs throughout the progression of primary and secondary renal disorders towards end‐stage renal disease. As a complex and irreversible pathophysiological phenomenon, it includes a sequence of intricate regulatory processes at the molecular and cellular levels. Exosomes are a distinct category of extracellular vesicles that play a crucial role in facilitating intercellular communication. Multiple pathways are regulated by exosomes produced by various cell types, including tubular epithelial cells and mesenchymal stem cells, in the context of renal fibrosis. Furthermore, research has shown that exosomes present in bodily fluids, including urine and blood, may be indicators of renal fibrosis. However, the regulatory mechanism of exosomes in renal fibrosis has not been fully elucidated. This article reviewed and analysed the various mechanisms by which exosomes regulate renal fibrosis, which may provide new ideas for further study of the pathophysiological process of renal fibrosis and targeted treatment of renal fibrosis with exosomes.

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The Role of Tumor Epithelial-Mesenchymal Transition and Macrophage Crosstalk in Cancer Progression

Cited by 3 publications

References 121 publications

Unfolding the mysteries of heterogeneity from a high-resolution perspective: integration analysis of single-cell multi-omics and spatial omics revealed functionally heterogeneous cancer cells in ccRCC

Unfolding the mysteries of heterogeneity from a high-resolution perspective: integration analysis of single-cell multi-omics and spatial omics revealed functionally heterogeneous cancer cells in ccRCC

Effect of lung metastasis on the treatment and prognosis of patients with gestational trophoblastic neoplasia: A systematic review and meta‐analysis

Exosomes on the development and progression of renal fibrosis

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