The Role of TRPV1 in Diabetes

Tsui, Hubert; Dorfman, Ruslan; Salter, Michael W.; Dosch, Hans‐Michael

doi:10.1002/9780470588284.ch16

Cited by 1 publication

(2 citation statements)

References 146 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Transient receptor potential vanilloid-1 (TRPV1) is the founding member of a growing family of complex neuronal sensors [5] that unexpectedly, play an important role in the non-obese diabetic (NOD) rodent model of T1D [6]. Indeed, TRPV1 maps to the idd4 locus with TRPV1 NOD , a unique hypofunctional mutant resulting from two amino acid substitutions that generate an overall hyposecretory phenotype [3].…”

Section: Sensory Neurons and Type 1 Diabetesmentioning

confidence: 99%

“…Afferent signalling routes through dorsal root ganglia and the spinal cord to the central nervous system [8,9]. However, as mentioned above, sensory neurons also have efferent function and in the case of T1D, release of sP into the islet milieu contributes to the regulation of β-cell insulin production (reviewed in [1,3,6]). …”

Section: Sensory Neurons and Type 1 Diabetesmentioning

confidence: 99%

See 1 more Smart Citation

‘Sensing’ the link between type 1 and type 2 diabetes

Tsui

Paltser

Chan

et al. 2011

Diabetes Metabolism Res

Self Cite

View full text Add to dashboard Cite

Obesity-associated insulin resistance is a core element of metabolic syndrome and type 2 diabetes (T2D). Notably, insulin resistance is also a feature of type 1 diabetes (T1D), where findings in the non-obese diabetic mouse model have implicated transient receptor potential vanilloid-1 (TRPV1+) sensory neurons in local islet inflammation and glucose metabolism. Here, we briefly review the role of TRPV1 in non-obese diabetic (NOD) T1D pathogenesis, highlighting commonalities that suggest TRPV1 may contribute to obesity and T2D as well. With the recently discovered importance of adipose infiltrating lymphocytes in the metabolic disturbances of obesity and T2D, sensory innervation of fat may thus play an analogous role to sensory neurons in the islet--modulating neuroendocrine homeostasis and inflammation. In such a scenario, TRPV1+ sensory nerves would provide the pathoaetiological link connecting the shared metabolic and immunologic features of type 1 diabetes and T2D.

show abstract

Section: Sensory Neurons and Type 1 Diabetesmentioning

confidence: 99%