The Role of Transforming Growth Factor α Formulation on Aspirin-Induced Ulcer Healing and Oxidant Stress in the Gastric Mucosa

Gönül, Bilge; Akbulut, K. Gonca; Özer, Çiğdem; Yetkin, Gülay; Çelebi, Nevin

doi:10.1007/s00595-004-2856-8

Cited by 13 publications

(3 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(26) Similarly, previous investigation suggested decrease of PAS staining during long-term administration of aspirin. (27) The current study showed that diclofenac sodium treatment increased iNOS expression and confirmed by a significant increase in the mean area percentage of iNOS as compared to the control. It was reported that nitric oxide is essential for normal mucosal function and has a role as cytoprotective on the gastrointestinal mucosa.…”

Section: Discussionsupporting

confidence: 68%

Modulating Effect of Vitamin D on iNOS, PCNA and a-SMA Expression Against Diclofenac Sodium Induced Gastric Injury in Rats

Youssef

2020

Indones Biomed J

View full text Add to dashboard Cite

BACKGROUND: Diclofenac sodium is a nonsteroidal anti-inflammatory prescription, widely used in the management of many inflammatory diseases but the side effects limiting its clinical use. The present work was carried out to detect the ameliorative effect of vitamin D against diclofenac sodium induced gastric injury in adult male albino rats.METHODS: Forty adult male Wistar albino rats were classified into four groups: G-I received no treatment (control group), G-II orally received 500 IU/kg of vitamin D daily, G-III intraperitoneally received 3 mg/kg of diclofenac sodium daily, and G-IV received both 500 IU/kg of vitamin D and 3 mg/kg of diclofenac sodium daily for 14 days. Specimens from rats' stomach were processed for light microscopy. Immunohistochemical examination was carried out to detect inducible nitric oxide synthase (iNOS), proliferating cell nuclear antigen (PCNA), and alpha smooth muscle actin (α-SMA). The morphometric results were analyzed statistically.RESULTS: Gastric sections of G-III displayed inflammatory cellular infiltrations and dilated congested blood vessels. Some of the gastric gland cells showed cytoplasmic vacuolation, dilated gastric pits, and cystic dilatation. There was a significant increased Masson's trichrome stain and a significant decrease in PAS. The mean area percentage of iNOS and α-SMA expression showed a statistically significant increase. The PCNA positive cells were significantly decreased in the isthmus and neck region compared with the control. While in contrast, G-IV prevented the gastric injury by increasing PAS and PCNA but decreasing Masson's trichrome stain, iNOS and α-SMA expression.CONCLUSION: Vitamin D administration prevented the structural alterations of the gastric rat induced by diclofenac sodium.KEYWORDS: diclofenac sodium, α-SMA, iNOS, PCNA, vitamin D

show abstract

Section: Discussionsupporting

confidence: 68%

Modulating Effect of Vitamin D on iNOS, PCNA and a-SMA Expression Against Diclofenac Sodium Induced Gastric Injury in Rats

Youssef

2020

Indones Biomed J

View full text Add to dashboard Cite

show abstract

“…Several studies showed that administration of growth factors positively effect normal and impaired wound healing (Steed, 1998;Ç elebi et al, 2002;Fujisawa et al, 2003;Gönül et al, 2004). In contrast to skin Table 1 The effects of EGF therapy on the GSH, AA Levels and MPO activity of oral wound strips after incisional operation GSH (lmol/g tissue) AA (mg/g tissue) MPO (U/g tissue) All data are expressed as the mean ± SD * p \ 0.05 in comparison to the untreated groups on the same day wound-healing models, there are few data about the effects of growth factors on healing of the oral mucosa.…”

Section: Discussionmentioning

confidence: 99%

Effect of exogenous epidermal growth factor (EGF) on nonenzymatic antioxidant capacities and MPO activity of wound tissue

et al. 2009

View full text Add to dashboard Cite

Growth factors and cytokines are key regulators of the wound-healing process. Epidermal growth factor (EGF) plays a vital role during the process of wound healing. There are limited numbers of studies related to EGF implantation effects on oxidative stress in oral wound healing. The objective of this study was to investigate the effect of EGF on myeloperoxidase (MPO) activity and nonenzymatic antioxidant levels of oral wound tissue on different days. In this study, New Zealand male albino rabbits were used. After submucosal incisions, the rabbits were divided into two equal groups: untreated wounds, and EGF-implanted wounds. The levels of glutathione (GSH), ascorbic acid (AA), and MPO activity were measured spectrophotometrically. As a result, MPO activity of oral wound tissue strips was increased by exogenous EGF treatment compared with controls. In addition, GSH and AA levels of oral wound tissue strips were not changed during oral wound-healing phases for both controls and experimental groups.

show abstract

“…Tannin, as a natural product, forms a protective layer in the stomach, increases resistance to injury and has antioxidant and anti-inflammatory properties (de Jesus et al, 2012;Demarque et al, 2018). TGFβ, a growth factor, improves ulcer healing by promoting cell migration, angiogenesis, and extracellular matrix production(Gönül et al, 2004;T. Tanigawa et al, 2005).…”

mentioning

confidence: 99%

The Relationship Manilkara zapota, Tumor Necrosis factor Alpha (TNFα) Transforming Growth Factor-β (TGFβ), and Gastric Ulcers

Rijal,

Miskad,

Changara

et al. 2023

JRTDD

View full text Add to dashboard Cite

Introduction: Gastric hyperacidity and gastroduodenal ulcers are serious global problems today. A disease found in many people throughout the world and often caused by excessive alcohol consumption. Important factors in the pathogenesis of acute gastric mucosal lesions induced by ethanol. The accumulation of ROS induces oxidative stress and causes gastric inflammation, gastric ulcers and perforation. This will trigger the expression of pro-inflammatory cytokines regulated by NF-кB and Activator protein 1 (AP-1). Interleukin (IL)-1b, IL-6 and tumor necrosis factor alpha (TNFα) are the two main cytokines involved in this inflammatory response. Objectives: The purpose of writing this review is to determine based on existing literature the effect of administering M. zapota fruit extract on the healing of gastric ulcers of Wistar rats induced by absolute ethanol by determining differences in ulcer scores, ulcer index, and PMN ( Polymophonuclear) leukocyte count in the stomach. Wistar rats induced by absolute ethanol and given M. zapota fruit extract, apart from that, also to determine the differences based on the immunoexpression of TNFα and TGF β Conclusions: Manilkara zapota has attracted attention in relation to the prevention of gastric ulcers. Several studies have shown that Manilkara zapota leaf extract has gastroprotective effects and may protect the gastric mucosa from damage induced by agents such as ethanol. In addition, Manilkara zapota is also believed to have a role in reducing the production of inflammatory factors, such as Tumor Necrosis Factor Alpha (TNFα) and Transforming Growth Factor-β (TGFβ).

show abstract

The Role of Transforming Growth Factor α Formulation on Aspirin-Induced Ulcer Healing and Oxidant Stress in the Gastric Mucosa

Abstract: These findings suggest that TGF-alpha accelerates the healing process after aspirin-induced gastric injury, and a relationship was observed between this application and the oxidative reactions.

Cited by 13 publications

References 22 publications

Modulating Effect of Vitamin D on iNOS, PCNA and a-SMA Expression Against Diclofenac Sodium Induced Gastric Injury in Rats

Modulating Effect of Vitamin D on iNOS, PCNA and a-SMA Expression Against Diclofenac Sodium Induced Gastric Injury in Rats

Effect of exogenous epidermal growth factor (EGF) on nonenzymatic antioxidant capacities and MPO activity of wound tissue

The Relationship Manilkara zapota, Tumor Necrosis factor Alpha (TNFα) Transforming Growth Factor-β (TGFβ), and Gastric Ulcers

Contact Info

Product

Resources

About