2014
DOI: 10.1111/ejn.12672
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Abstract: Amylin reduces meal size by activating noradrenergic neurons in the area postrema (AP). Neurons in the AP also mediate the eating-inhibitory effects of salmon calcitonin (sCT), a potent amylin agonist, but the phenotypes of the neurons mediating its effect are unknown. Here we investigated whether sCT activates similar neuronal populations to amylin, and if its anorectic properties also depend on AP function. Male rats underwent AP lesion (APX) or sham surgery. Meal patterns were analysed under ad libitum and … Show more

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Cited by 46 publications
(54 citation statements)
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“…Rats weighing between 190 and 250 g underwent AP lesions as reported [18]. Briefly, animals were anesthetized as described above and the rats’ head was flexed ventrally at an approximate 110° angle in a stereotaxic frame.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Rats weighing between 190 and 250 g underwent AP lesions as reported [18]. Briefly, animals were anesthetized as described above and the rats’ head was flexed ventrally at an approximate 110° angle in a stereotaxic frame.…”
Section: Methodsmentioning
confidence: 99%
“…Animals were left to recover for 8 days, after which lesions were verified using a within-subject crossover test of 1-h food intake in response to an injection of 20 μg/kg amylin or saline i.p. after 12 h food restriction [18]. FSCV was then performed on rats between postoperative days 14–18.…”
Section: Methodsmentioning
confidence: 99%
“…Amylin receptors have been identified in various brain areas including area postrema, nucleus of the solitary tract and dorsal raphe among others (Sexton et al 1994). In fact, amylin and sCT express their anorexigenic effects through central mechanisms involving the area postrema and the nucleus of the solitary tract (Lutz et al 2001a;Potes & Lutz 2010;Braegger et al 2014). Recent studies show that amylin receptors in the NAc, VTA and LDTg (Baisley & Baldo 2014;Mietlicki-Baase et al 2015a;Reiner et al 2017) and more specifically amylin receptors on ventral tegmental dopaminergic neurons mediate the effect of sCT on the control of energy balance (Mietlicki-Baase et al 2013;Mietlicki-Baase et al 2015b).…”
Section: Introductionmentioning
confidence: 99%
“…61 Part of the amylin-activated AP neurons seem to express dopamine-β-hydroxylase, which characterizes noradrenergic neurons. In fact,~50% of amylin activation seems to occur in neurons expressing dopamine-β-hydroxylase 39,62 while the phenotype of the remainder of amylin-activated neurons is unclear; at least part of them may be second-order neurons, which therefore do not necessarily express amylin receptors and the amylin signaling transduction machinery themselves.…”
Section: Amylin and Glp-1 Receptor Functionmentioning
confidence: 99%
“…34 Further, GLP-1's eating-inhibitory action seems to differ between fasted versus fed animals because GLP-1 decreased eating when administered to rats after refeeding with a 3 g meal, but not when administered in the fasted state; 63 amylin, in contrast, has been shown to reduce eating when administered to fasted or ad libitum fed animals (for example, Lutz et al, 43 Braegger et al 62 and Michel et al 64 ). The increased effectiveness of GLP-1 to reduce eating in refed animals may be related to an increase in the GLP-1 receptor translocation to the cellular membrane of vagal afferent neurons; the cell bodies of these neurons are located in the nodose ganglion.…”
Section: Amylin and Glp-1 Receptor Functionmentioning
confidence: 99%