Abstract:Up to 60% of colorectal cancer (CRC) patients develop cachexia. The presence of CRC related cachexia is associated with more adverse events during systemic therapy, leading to a high mortality rate. The main manifestation in CRC related cachexia is the loss of skeletal muscle mass, resulting from an imbalance between skeletal muscle protein synthesis and protein degradation. In CRC related cachexia, systemic inflammation, oxidative stress, and proteolytic systems lead to mitochondrial dysfunction, resulting in… Show more
“…Van de Haterd et al [8] reviewed the role of mitochondria in skeletal muscle atrophy during colorectal cancer cachexia (CRC). Mitochondria homeostasis plays an important role in muscle maintenance.…”
“…Van de Haterd et al [8] reviewed the role of mitochondria in skeletal muscle atrophy during colorectal cancer cachexia (CRC). Mitochondria homeostasis plays an important role in muscle maintenance.…”
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